Evidence map›Paper›PMID 40619672›Full record

ArticleGut microbes2025

Minimal logic gates for probiotic

Haoran Li, Shanshan Zhang, Jinyan Yin, Gege Wang, Qi Wang, Yongzhen Xia, Lixiang Li, Qingsheng Qi, Qian Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haoran LiNational Glycoengineering Research Center, Shandong University, Qingdao, P. R. China.
Shanshan ZhangDepartment of Gastroenterology, Qilu Hospital, Shandong University, Jinan, P.R. China.
Jinyan YinNational Glycoengineering Research Center, Shandong University, Qingdao, P. R. China.
Gege WangNational Glycoengineering Research Center, Shandong University, Qingdao, P. R. China.
Qi WangNational Glycoengineering Research Center, Shandong University, Qingdao, P. R. China.
Yongzhen XiaState Key Laboratory of Microbial Technology, Shandong University, Qingdao, P. R. China.ORCID 0000-0001-9950-1910
Lixiang LiDepartment of Gastroenterology, Qilu Hospital, Shandong University, Jinan, P.R. China.
Qingsheng QiState Key Laboratory of Microbial Technology, Shandong University, Qingdao, P. R. China.
Qian WangNational Glycoengineering Research Center, Shandong University, Qingdao, P. R. China.ORCID 0000-0003-3135-9385

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid development of synthetic biology has led to engineered probiotics to address the growing concern of infectious diseases and cancer. Dual or multiple bacterial infections are becoming more frequent, but there are few treatment options because complex approaches are needed to address different disease mechanisms. In this study, we designed a minimal logic gate to program

Indexed as

Escherichia coliIntestinal DiseasesProbioticsPseudomonas InfectionsAnimalsDisease Models, AnimalHumansMicePseudomonas aeruginosaSynthetic BiologyYersinia enterocoliticadirectional chemotaxisdual-bacterial infectionEngineered probioticslogic gateP. aeruginosaY. enterocolitica

Identifiers

PMID40619672
PMCPMC12239797

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.