Evidence map›Paper›PMID 40619595›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer.

Joshua J Milligan, Rachel L Strader, Arunangshu Chakrabarty, Max Ney, Parul Sirohi, Jonathan C Su, Anastasia K Varanko, Yulia Shmidov, Kalina Tsolova, Cassio Mendes Fontes and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Joshua J MilliganDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0001-6370-1101
Rachel L StraderDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0009-0009-1873-8525
Arunangshu ChakrabartyDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Max NeyDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0001-8244-1683
Parul SirohiDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0002-5791-3383
Jonathan C SuDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Anastasia K VarankoDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0003-2763-5842
Yulia ShmidovDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0003-4152-0670
Kalina TsolovaDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0003-4537-6303
Cassio Mendes FontesDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0003-3157-478X
Anna FinkelsteinDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0003-1257-7838
Rohinee MattikalliDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Yun-Xing WangCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Fredrick, MD, 21702, USA.
Lixin FanBasic Science Program, Fredrick National Laboratory for Cancer Research, SAXS Facility of the National Cancer Institute, Fredrick, MD, 21702, USA.
Xinghai LiDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Smita K NairDepartment of Surgery, Duke University Medical Center, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0001-7019-1912
Ashutosh ChilkotiDepartment of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.ORCID https://orcid.org/0000-0002-1569-2228

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8M
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
A Simultaneous SAXS/WAXS Detector System for Solving Biological StructuresS10OD012331 · OD · STATE UNIVERSITY NEW YORK STONY BROOK · PI ALLAIRE, MARC · 2012 to 2012
$1.1M
DOE Office of Biological and Environmental Research KP1605010National Science Foundation ECCS-2025064NCI NIH HHS 75N91019D00024NCI NIH HHS P30 CA014236NIGMS NIH HHS P30 GM133893NIGMS NIH HHS P30GM133893NIH HHS S10 OD012331North Carolina Biotechnology Center #2017-IDG-1018U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences Program DE-SC0012704
6 · The paper itself

Abstract

Biomaterials can improve cancer immunotherapies by controlling their release and thereby optimizing their time-dependent engagement of the immune system. In this study, an approach is described to control the release of a potent immunostimulant-CpG oligodeoxynucleotide-from a genetically-encoded elastin-like polypeptide (ELP) depot. A CpG-binding ELP containing an oligolysine domain (ELP-Lys

Indexed as

Adjuvants, ImmunologicImmunotherapyOligodeoxyribonucleotidesAnimalsCell Line, TumorElastinFemaleHumansKineticsMiceNeoplasm MetastasisAdjuvants, ImmunologicCPG-oligonucleotideElastinOligodeoxyribonucleotidesbiopolymersdrug deliveryelastin‐like polypeptidesimmunotherapy

Identifiers

PMID40619595
PMCPMC12499502

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.