Evidence map›Paper›PMID 40619491›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2025

Lower high-density lipoprotein cholesterol level is associated with hematoma expansion in acute intracerebral hemorrhage: association with hypertensive microangiopathy.

Takeo Sato, Yuka Tsuchimochi, Yuki Hamada, Kaishi Kukihara, Yutaro Kawabata, Kana Iwamoto, Go Takaguchi, Yujiro Higuchi, Hideki Matsuoka, Hiroshi Takashima

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takeo SatoDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan. takeo.sato.821@gmail.com.
Yuka TsuchimochiDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Yuki HamadaDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Kaishi KukiharaDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Yutaro KawabataDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Kana IwamotoDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Go TakaguchiDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Yujiro HiguchiDepartment of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Hideki MatsuokaDepartment of Strokology, Stroke Center, National Hospital Organization Kagoshima Medical Center, Kagoshima, Japan.
Hiroshi TakashimaDepartment of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The correlation between lipoprotein cholesterol levels and hematoma expansion (HE) following intracerebral hemorrhage (ICH) remains unknown. We aimed to elucidate the correlation between high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and HE following acute ICH in entire ICH, non-lobar ICH, and lobar ICH cohorts. Consecutive patients with ICH between July 2012 and November 2023 were screened. The inclusion criteria were: (1) onset to door time within 24 h; (2) availability of serum HDL-C and LDL-C level evaluations on admission; and (3) availability of HE evaluation. We investigated the association between HDL-C and LDL-C levels and HE using Poisson regression analyses with a robust variance estimator in three models with adjustment for various factors. Screening of 608 consecutive ICH patients revealed 409 with acute ICH (204 [50%] males, median age 75 years). HE was observed in 43 patients (11%). In the entire ICH cohort, lower HDL-C was independently associated with HE in all the study models (p < 0.05). Further, a negative linear association was observed between HDL-C quartiles and HE in reference to HDL-C Quartile 4 in all the models (p < 0.05 for trend). These significant associations were also observed in the non-lobar ICH cohort, but not in the lobar ICH cohort. LDL-C was not associated with HE in any of the cohorts. In acute ICH patients, lower HDL-C was associated with HE, especially in the non-lobar ICH cohort generally caused by hypertensive microangiopathy. HDL-C might have protective potential against HE following ICH. We aimed to elucidate the correlation between high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and hematoma expansion (HE) following acute intracerebral hemorrhage (ICH). Lower HDL-C was associated with HE, especially in the non-lobar ICH caused by hypertensive microangiopathy. HDL-C might have protective potential against HE following ICH.

Indexed as

Cerebral HemorrhageCholesterol, HDLHematomaHypertensionAgedAged, 80 and overCholesterol, LDLFemaleHumansMaleMiddle AgedCholesterol, HDLCholesterol, LDLHigh-density lipoprotein cholesterolIntracerebral HemorrhageLow-density lipoprotein cholesterolRisk factorStroke

Identifiers

PMID40619491

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.