ArticleBMC veterinary research2025
Molecular profile PCR array of regenerative therapy (PRP, PRF& CpG-ODN) in wound healing of diabetic dogs.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Chitosan and chitosan-silver nanoparticles as adjuncts to platelet-rich plasma in canine full-thickness cutaneous wound healing.Journal of materials science. Materials in medicine · 2026Article
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Authors and funding
3 authors.
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Abstract
This study's aim is to validate differential wound healing genes expression in canine with diabetes using regenerative medicine such as PRP, PRF, and CpG oligodeoxynucleotides (ODN), for these purpose thirty six diabetic dogs were used and subdivided into 6 groups (6 dogs each) with full-thickness incisional wounds, wound healing was evaluated with a focus on histological changes in wound tissue and gene expression after 3 weeks. The molecular mechanism of wound healing responding to different treatments in dogs were done using the new molecular technique RT2 Profiler PCR array (Qiagen), which enables us to view a focused panel of genes (84 genes) responsible for wound healing. CpG-ODN contributes to low cellular infiltration; PRP improves diabetic wound closure rapidly. The study illustrated that the healing rate was higher in the PRP & CpG-ODN. The animal in this group showed a clinically higher contraction rate of the wound area, upregulates 37 genes responsible for wound healing and downregulates ten genes for the same purpose, also marked collagen production were observed with complete epithelialization. Our study concluded that PRP & CpG-ODN was superior to PRF & CpG-ODN, PRP, PRF, CpG-ODN, and the control group, respectively, for enhancing wound healing in diabetic dogs.
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