Evidence map›Paper›PMID 40619332›Full record

ArticleEuropean urology focus2025

KIM-1 as a Prognostic Marker in Renal Cell Carcinoma.

Clara Steiner, Marc Machaalani, Joseph V Bonventre, David F McDermott, Toni K Choueiri, Wenxin Xu

Abstract read
In one paragraph

Article in European urology focus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Clara SteinerDana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Marc MachaalaniDana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Joseph V BonventreHarvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA.
David F McDermottHarvard Medical School, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA.
Toni K ChoueiriDana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Wenxin XuDana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: wenxin_xu1@dfci.harvard.edu.

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6M
Treating the P13-Kinase/AKTP50CA101942 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI David McDermott · 2003 to 2026
$53.4M
KIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIRR01DK072381 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2005 to 2025
$8.6M
Mechanisms of Ischemic Kidney Injury and RepairR01DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JOSEPH VINCENT BONVENTRE · 1987 to 2026
$6.2M
Mechanisms of Ischemic Kidney Injury and RepairR37DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1993 to 2021
$5.2M
Tissue-based biomarkers of anti-PD-1-based therapy in metastatic renal cell carcinomaR01CA266424 · NCI · DANA-FARBER CANCER INST · PI Toni Choueiri, SABINA SIGNORETTI · 2022 to 2026
$3.6M
Assessment of germline variants associated with immune-related adverse events following immune checkpoint inhibitorsR01CA293091 · NCI · DANA-FARBER CANCER INST · PI Toni Choueiri, ALEXANDER GUSEV · 2024 to 2026
$3.5M
Clinical characterization of Kidney Injury Molecule-1 (KIM-1) as a Biomarker in Renal Cell CarcinomaR01CA258442 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI David McDermott · 2022 to 2026
$2.1M
NCI NIH HHS P30 CA006516NCI NIH HHS P50 CA101942NCI NIH HHS R01 CA258442NCI NIH HHS R01 CA266424NCI NIH HHS R01 CA293091NIDDK NIH HHS R01 DK039773NIDDK NIH HHS R01 DK072381NIDDK NIH HHS R37 DK039773
6 · The paper itself

Abstract

There is an unmet need for a noninvasive biomarker in renal cell carcinoma. KIM-1 has emerged as a compelling candidate according to retrospective evidence and post hoc analyses of prospective trials. Prospective studies are needed for validation and clinical implementation.

Indexed as

Biomarkers, TumorCarcinoma, Renal CellHepatitis A Virus Cellular Receptor 1Kidney NeoplasmsHumansPrognosisBiomarkers, TumorHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1

Identifiers

PMID40619332
PMCPMC13478781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.