ArticleNeuroscience letters2025
Spinal activation of TRPV1-mediated attenuation of a chemoreflex: Potential mechanism of action linking TRPV1 activation with modulation of Ca
Article in Neuroscience letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The objective of the present study was to examine the effect of intrathecal injection of the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, on the spinal transmission of the pressure reflex induced by intra-arterial administration of capsaicin (chemoreflex). In decerebrated rats, we found that intrathecal injection of capsaicin attenuated significantly the increase in arterial pressure evoked by intra-arterial capsaicin when compared to intrathecal injection of saline. Afterwards, whole-cell patch-clamp technique was employed to determine if TRPV1 activation was involved in the modulation of voltage-gated Ca
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