Evidence map›Paper›PMID 40618727›Full record

ArticleRespiration; international review of thoracic diseases2025

Mini-Invasive Pleural Probe-Based Confocal Laser Endomicroscopy for Malignant Pleural Effusion Diagnosis.

Olivier Bonhomme, Vincent Heinen, Jean-Louis Corhay, Renaud Louis, Nancy Detrembleur, Bernard Duysinx

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PubMed Full text at PMC Publisher
In one paragraph

Article in Respiration; international review of thoracic diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olivier BonhommePneumology Department, CHU Liège, Liège, Belgium.
Vincent HeinenPneumology Department, CHU Liège, Liège, Belgium.
Jean-Louis CorhayPneumology Department, CHU Liège, Liège, Belgium.
Renaud LouisPneumology Department, CHU Liège, Liège, Belgium.
Nancy DetrembleurPathology Department, CHU Liège, Liège, Belgium.
Bernard DuysinxPneumology Department, CHU Liège, Liège, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: Probe-based confocal laser endomicroscopy (pCLE) is an optical imaging tool which allows live imaging tissues at cellular level. pCLE proved to be able to discriminate malignant from benign pleura during medical thoracoscopy and can identify malignant cells in pleural fluids. Since pleural fluid cytology has limited sensitivity for malignant pleural effusion diagnosis, we wanted do determine the feasibility, the safety, and the yield of mini-invasive close-blinded pleural pCLE.

methodsWe conducted a single-center prospective trial. Every patient referred to medical thoracoscopy because of pleural effusion was eligible. Thoracocentesis for pleural fluid analysis was performed first with a Boutin's needle. Second, the probe was introduced in the pleural space through the Boutin's needle for mini-invasive pleural pCLE. Finally, the medical thoracoscopy and invasive pleural pCLE were performed. Seven pCLE criteria were prospectively rated to assess the sensitivity and specificity of mini-invasive pleural pCLE for malignant pleural effusion diagnosis.

resultsFifty-two patients were enrolled. Mini-invasive pleural pCLE was feasible and safe. Pathological pleural fluid analysis identified malignant effusion with 42% sensitivity and 100% specificity. For the mini-invasive pleural pCLE, five of 7 criteria proved to be significantly discriminant between malignant and benign pleura. Overall, mini-invasive pleural pCLE had 87% sensitivity for malignant pleural effusion identification. The specificity is 52%, and the positive and negative predictive value were 73% both.

conclusionMini-invasive pleural pCLE was safe and feasible and its sensitivity for malignant pleural infiltration diagnosis was much higher than pleural fluid cytology. </p>.

Indexed as

Pleural Effusion, MalignantAdultAgedAged, 80 and overFeasibility StudiesFemaleHumansMaleMicroscopy, ConfocalMiddle AgedProspective StudiesSensitivity and SpecificityThoracentesisThoracoscopyMalignant pleural effusionPleural biopsiesPleural fluid cytologyPleural malignanciesProbe-based confocal laser endomicroscopy

Identifiers

PMID40618727
PMCPMC12503441

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.