ReviewCurrent opinion in immunology2025
The role of epigenetic modifications in systemic autoinflammatory diseases.
Review in Current opinion in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- From metabolic node to smart building block: α-Ketoglutarate-empowered biomaterials for programmable cell fate.Materials today. Bio · 2026Review
- Targeting the cytokine-epigenetic axis: a new paradigm and prospects for disease treatment.European cytokine network · 2026Review
- Programmed cell death in osteoarthritis.Apoptosis : an international journal on programmed cell death · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Autoinflammatory diseases are a group of immune dysregulation disorders, with genetic mutations identified in approximately 50% of patients. However, patients with known pathogenic mutations may display a broad range of phenotypic diversity. Epigenetic modifications play a crucial role in regulating immune-mediated diseases, including autoinflammatory diseases, influencing disease course and complications. This review provides an overview of the current literature on the role of epigenetic changes in autoinflammatory diseases, examining their implications for disease mechanisms. To identify biological processes and pathways influenced by microRNAs across autoinflammatory diseases, we performed enrichment analyses in Gene Ontology biological processes. This analysis revealed enriched pathways reflecting the varying biological mechanisms implicated in familial Mediterranean fever (FMF), tumor necrosis factor associated periodic syndrome (TRAPS), and neonatal-onset multisystem inflammatory disease (NOMID). Notably, FMF was linked to clinically significant pathways, including those related to cytokine production, cardiovascular system, and neuroinflammation. These results highlight the potential of epigenetic modifications as biomarkers for autoinflammatory diseases. Given the role of epigenetic modifications in gene expression and the growing interest in their involvement in disease pathogenesis and therapy, including in rare disorders, further research into the epigenetic landscape of autoinflammatory diseases is essential. Furthermore, integrating genetic, epigenetic, and environmental factors will be key to addressing clinical variability and developing personalized treatment approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.