Evidence map›Paper›PMID 40618485›Full record

ArticleNeurobiology of aging2025

Identifying lifestyle risk factors that discriminate memory trajectories: Differential findings across racial and ethnic groups in older adults.

Shraddha Sapkota, Pauline Maillard, Evan M Fletcher, Danielle J Harvey, John M Olichney, Sarah Tomaszewski Farias, Paola Gilsanz, Dan Mungas, Rachel A Whitmer, Charles DeCarli

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In one paragraph

Article in Neurobiology of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Shraddha SapkotaDepartment of Neurology, University of California, Davis, CA 95618, USA. Electronic address: sapkota@ucdavis.edu.
Pauline MaillardDepartment of Neurology, University of California, Davis, CA 95618, USA.
Evan M FletcherDepartment of Neurology, University of California, Davis, CA 95618, USA.
Danielle J HarveyDepartment of Neurology, University of California, Davis, CA 95618, USA.
John M OlichneyDepartment of Neurology, University of California, Davis, CA 95618, USA.
Sarah Tomaszewski FariasDepartment of Neurology, University of California, Davis, CA 95618, USA.
Paola GilsanzDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA 94588, USA.
Dan MungasDepartment of Neurology, University of California, Davis, CA 95618, USA.
Rachel A WhitmerDepartment of Neurology, University of California, Davis, CA 95618, USA; Department of Public Health Sciences, University of California, Davis, USA.
Charles DeCarliDepartment of Neurology, University of California, Davis, CA 95618, USA.

Funding

UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)R01AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GILSANZ, PAOLA, GLYMOUR, MEDELLENA MARIA · 2021 to 2025
$18.0M
Brain pathologies, reserve and cognition in aging and dementiaR01AG031563 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Evan Fletcher, SARAH E TOMASZEWSKI-FARIAS · 2009 to 2026
$8.9M
Phase II RCT of High-dose Vitamin D Supplements in Older Adults without DementiaR01AG051618 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI OLICHNEY, JOHN M · 2017 to 2023
$5.2M
NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG031563NIA NIH HHS R01 AG051618NIA NIH HHS R01 AG052132
6 · The paper itself

Abstract

introductionDifferences in lifestyle factors contribute towards inequalities in dementia incidence and memory trajectories across racial and ethnic groups. We identifieded lifestyle risk factors that best discriminat memory trajectories in older adults without cognitive impairment.

methodThe study included 523 older adults from the University of California, Davis-Alzheimer's disease Research Center and 1097 from the Kaiser Healthy-Aging and Diverse Life-Experiences Study. Age, sex, and 13 lifestyle risk factors were used to discriminate latent class memory trajectories in African Americans, Hispanics, and Whites. Structural equation modeling and machine learning methods were applied.

resultsIn both cohorts, three patterns of memory trajectories were identified. While there was overlap between risk factors discriminating high and low memory patterns for everyone, we also identified key differences in the top predictors across groups in both cohorts. DISCUSSION: Identifying relative importance of lifestyle risk factors will promote early identification of adults with differential memory performance across and within racial and ethnic groups.

Indexed as

EthnicityLife StyleMemoryRacial GroupsAgedAged, 80 and overBlack or African AmericanCohort StudiesDementiaFemaleHispanic or LatinoHumansMachine LearningMaleRisk FactorsWhiteEthnicityKHANDLELatent class analysisLifestyle risk factorsMachine learningMemory

Identifiers

PMID40618485
PMCPMC13017100

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.