Evidence map›Paper›PMID 40618377›Full record

ReviewGut microbes2025

Current state of microbiota clinical applications in neonatal and pediatric bacterial infections.

Thanh Thien Le, Tram Ngoc Hoang, Dylan Huy Do, Xuan-Hung Nguyen, Cynthia Huynh, Hang Dao Viet, Vu Quoc Dat, Karsten Zengler, Jack A Gilbert, Sean N Avedissian and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. MaternalBiomedicines · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Thanh Thien LeVinmec-VinUni Institute of Immunology, College of Health Science, VinUniversity, Hanoi, Vietnam.ORCID 0000-0002-7756-9479
Tram Ngoc HoangUniversity of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA, USA.
Dylan Huy DoDepartment of Biological Sciences, Dartmouth College, Hanover, NH, USA.
Xuan-Hung NguyenVinmec-VinUni Institute of Immunology, College of Health Science, VinUniversity, Hanoi, Vietnam.ORCID 0000-0002-2216-8598
Cynthia HuynhUniversity of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA, USA.
Hang Dao VietInternal Medicine Faculty, Hanoi Medical University, Hanoi, Vietnam.
Vu Quoc DatDepartment of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam.ORCID 0000-0002-5904-5970
Karsten ZenglerDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-8062-3296
Jack A GilbertDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-7920-7001
Sean N AvedissianAntiviral Pharmacology Laboratory, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-0935-6455
Tri Minh TranInternal Medicine, Kaiser Permanente, Los Angeles, CA, USA.
Jennifer LeUniversity of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA, USA.ORCID 0000-0002-6692-0884

Funding

NIH HHS R01DK14032801
6 · The paper itself

Abstract

The microbiota plays a crucial role in pediatric health by shaping immune development and influencing infection susceptibility. In infants and children, an immature microbiota may compromise immune defense, increasing the risk of bacterial infections. This review evaluates clinical trials on the microbiota's role in neonatal and pediatric bacterial infections, including sepsis, infections in pediatric cancer patients, and

Indexed as

Bacterial InfectionsGastrointestinal MicrobiomeAnti-Bacterial AgentsBacteriaChildChild, PreschoolDysbiosisFecal Microbiota TransplantationHumansInfantInfant, NewbornProbioticsAnti-Bacterial Agentsacute lymphoblastic leukemiaantibioticsbloodstream infectioncancerchildrenClostridioides difficilefecal microbiota transplantationgut microbiomehematopoietic stem cell transplantationinfectionMicrobiomenasopharyngeal microbiomeneonatesoral microbiomepediatricsprobioticssepsisvolatile organic compounds

Identifiers

PMID40618377
PMCPMC12233708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.