Observational studyNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2026
Calf circumference predicts sarcopenia and all-cause mortality in older patients undergoing maintenance hemodialysis: A prospective cohort study.
Observational study in Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Screening effect of phase angle and calf circumference in different stages of sarcopenia in patients with maintenance hemodialysis.BMC musculoskeletal disorders · 2026Article
- Global leadership initiative on malnutrition criteria using different muscle mass assessment methods in hemodialysis patients: Links to physical performance, quality of life, and clinical outcomes.European journal of clinical nutrition · 2026Article
- Agreement between bioimpedance-measured and calf-derived appendicular skeletal muscle mass in amyotrophic lateral sclerosis patients.European journal of clinical nutrition · 2026Article
- Calf circumference predicts sarcopenia and all-cause mortality in older patients undergoing maintenance hemodialysis: A prospective cohort study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Observational
- A retrospective analysis of clinical characteristics and risk factors of renal anemia in elderly patients on maintenance hemodialysis.Medicine · 2025Observational
- Feeding Modality and Longitudinal Nutritional Status in Severe Dementia: A Matched Cohort Study.American journal of Alzheimer's disease and other dementiasArticle
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe role of calf circumference (CC) in predicting sarcopenia and mortality of patients undergoing maintenance hemodialysis (MHD) remains debated. This study assessed CC's predictive value, optimal threshold, and mortality association in older patients undergoing MHD.
methodsAn observational cohort study was conducted on older adult patients undergoing MHD. Sarcopenia was defined by European Working Group on Sarcopenia in Older People. Logistic regression and receiver operating characteristic (ROC) analysis were used to explore the relationship between CC and sarcopenia. Kaplan-Meier and Cox regression analyses assessed survival over 2 years.
resultsA total of 979 older adult patients undergoing MHD treatment, with an average age of 73.4 years, were included in this study. The prevalence of sarcopenia was 61.1%. Male sex (odds ratio [OR], 0.17; 95% confidence interval [CI], 0.04-0.45; P = 0.017) and CC (OR, 0.38; 95% CI, 0.26-0.56; P < 0.001) were identified as independent risk factors for sarcopenia through multifactorial logistic regression analysis. ROC curves for CC and sarcopenia indicated that the optimal cutoff value for men was 32.5 cm (area under the curve [AUC], 0.904; sensitivity, 0.958; specificity, 0.841), whereas for women, it was 31.9 cm (AUC, 0.884; sensitivity, 0.922; specificity: 0.756). Kaplan-Meier survival analysis demonstrated lower survival probabilities in patients with sarcopenia and low CC. After adjustment for multiple factors, Cox regression analysis revealed that patients in the sarcopenia group (hazard ratio [HR] = 2.411; P = 0.017) and those in the low-CC group (HR = 2.045; P = 0.046) had significantly shorter overall survival.
conclusionsCC is an independent predictor of sarcopenia and mortality in older patients undergoing MHD.
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