Trial reportBMC oral health2025
Clinical and radiographic evaluation of topical vitamin D application on immediate dental implants: a randomized clinical trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06806423 (Clinical and Radiographic Evaluation of Topical Vitamin D Application on Immediate Dental Implants), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Radiographic Evaluation of Topical Vitamin D Application on Immediate Dental Implants: a Randomized Clinical Trial
Who cites it
2 citing papers in PubMed.
- Clinical and radiographic evaluation of natural bovine bone with hyaluronic acid on osseointegration of immediate implants: a randomized clinical study.Scientific reports · 2026Trial
- Vitamin D in Peri-Implant and Periodontal Tissue.Dentistry journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImmediate dental implants reduced treatment time and improved patient satisfaction, but achieving optimal osseointegration remained challenging. Bioactive agents, such as growth factors, cytokines and vitamins, are explored for their roles in enhancing bone healing and implant osseointegration. Vitamin D3 (calcitriol) showed promising potential in promoting these processes. This study aimed to evaluate the clinical and radiographic effects of topical vitamin D3 (calcitriol) gel on immediate dental implants.
methodsTwenty-four immediate implants were placed in healthy patients (aged 21–40 years) requiring replacement of single-rooted teeth in the anterior mandible. Patients were randomly allocated to either the control group (Group I: 12 implants inserted after tooth extraction) or the study group (Group II: 12 implants inserted after tooth extraction with topical vitamin D3 (calcitriol) gel). Clinical evaluations, including peri-implant probing depth, bleeding index, pain score and implant stability, were performed at baseline, 3 and 6 months postoperatively. Radiographic evaluation, represented by bone density analysis was conducted at the same intervals.
resultsAfter 6 months, the Vitamin D group showed significant improvement in soft tissue healing with greater reductions in probing depth and bleeding index (1.17 mm and 0.58 vs. 1.83 mm and 1.42, respectively). Postoperative pain scores were significantly lower in the Vitamin D group by day 7 (1.00 vs. 2.50), reflecting an 81.2% reduction compared to the control group. Implant stability significantly reached 80 ISQ in the Vitamin D group compared to 75 ISQ in the control group. Bone density was significantly higher in the Vitamin D group (139.01 vs. 121.01 GSV), increasing by 18.1% vs. 6.4% in the control group.
conclusionsThe reductions in peri-implant probing depth and bleeding index reflected improved soft tissue healing. The decrease in postoperative pain scores suggested potential analgesic effects. The increase in implant stability and bone density indicated enhanced osseointegration. These findings support the clinical application of topical vitamin D3 for immediate dental implant placement to promote peri-implant soft and hard tissue healing.
trial registrationNCT06806423 (registration date: January 28, 2025).
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