Observational studyBMC oral health2025
Is medical therapy alone efficient for the management of Medication-related osteonecrosis of the jaw bones (MRONJ) in all stages?: a comparative single-center case-control study.
Observational study in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06917846 (Is Medical Therapy Alone Efficient for the Management of Medication-Related Osteonecrosis of the Jaw Bones), which is not on this map. Cited by 2 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is Medical Therapy Alone Efficient for the Management of Medication-Related Osteonecrosis of the Jaw Bones (MRONJ) in All Stages?: A Comparative Study
Who cites it
2 citing papers in PubMed.
- Florid Cemento-Osseous Dysplasia with Superimposed Infection Mimicking MRONJ and Plasma Cell Neoplasia: A Clinicoradiopathologic Image-Based Challenge.Diagnostics (Basel, Switzerland) · 2026Article
- A scientometric study on research trends and characteristics of medication-related osteonecrosis of the jaw.Journal of dental sciences · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe management of medication-related osteonecrosis of the jaw (MRONJ) is challenging, and there is ongoing debate over whether medical or surgical treatment is the gold standard. The aim of this retrospective study is to investigate the efficacies of medical and surgical treatments of MRONJ and comparatively evaluate their outcomes.
methodsThis study analyzed 116 MRONJ lesions in 102 patients, divided into medical and surgical treatment groups. Outcomes after 12 months were categorized into four healing response groups. Associations between variables and outcomes were assessed using Chi-Square and Fisher’s exact tests.
resultsAll stage 1 MRONJ lesions showed complete healing (H1), regardless of the treatment modality. In stage 2 MRONJ lesions, no statistically significant difference was found between two treatment approaches (p = 0.693). In contrast, for stage 3 MRONJ lesions, treatment outcomes differed significantly between groups (p = 0.007). Secondary osteonecrosis occurred in 71.4% of stage 3 lesions that were treated surgically (p = 0.003). Spontaneous sequestration occurred in 56 lesions as an outcome of the medical therapy(n:71). A statistically significant correlation was found between healing outcomes and spontaneous sequestration (p < 0.001).
conclusionsIn conclusion, the antibiotherapy protocol is a safe and effective non-surgical option for MRONJ management, promoting necrotic bone sequestration with reduced complications and high recovery potential.
trial registrationThis study is retrospectively registered. Clinical Trial Registration (ID NCT06917846, Date 20250409, [ http://clinicaltrials.gov/study/NCT06917846 ]).
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