Evidence map›Paper›PMID 40618138›Full record

SynthesisEuropean journal of medical research2025

Non-invasive neurally adjusted ventilatory assist versus nasal continuous positive airway pressure for premature infants: a systematic review and meta-analysis.

Yuan Yuan, Fang He, Dehua Wu, Hongmei Zou

Abstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuan YuanDepartment of Neonatology, Guangzhou Women and Children's Medical Center，Guangzhou Medical University, No.9 Jinsui Road, Tianhe District, Guangzhou City, 510600, Guangdong Province, People's Republic of China.
Fang HeDepartment of Neonatology, Guangzhou Women and Children's Medical Center，Guangzhou Medical University, No.9 Jinsui Road, Tianhe District, Guangzhou City, 510600, Guangdong Province, People's Republic of China.
Dehua WuInstitute of Pediatrics, Clinical Data Center , Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou City, 510600, Guangdong Province, People's Republic of China.
Hongmei ZouDepartment of Neonatology, Guangzhou Women and Children's Medical Center，Guangzhou Medical University, No.9 Jinsui Road, Tianhe District, Guangzhou City, 510600, Guangdong Province, People's Republic of China. hongmeizou_neo@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this study was to compare the benefits of non-invasive neurally adjusted ventilatory assist (NIV-NAVA) versus Nasal continuous positive airway pressure (NCPAP) as respiratory support for premature infants.

methodsLiterature on NIV-NAVA and NCPAP as respiratory support of premature infants was comprehensively searched from PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP database. The search time was from the establishment of the database to June 20, 2023. Meta-analysis was performed by RevMan 5.4 software. The rate of extubation failure, need for intubation, surfactant therapy, as well as the adverse outcomes of bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), and pneumothorax were compared between NIV-NAVA group and NCPAP group.

results5 eligible randomized controlled trials involving 326 newborns were included. No significant difference was found in the above 7 indexes between NIV-NAVA and NCPAP.

conclusionsCompared with NCPAP, NIV-NAVA has not obtained significant advantages in premature infants yet. However, NIV-NAVA is still a potential non-invasive mechanical ventilation method, which needs more research to confirm.

Indexed as

Continuous Positive Airway PressureInfant, PrematureInteractive Ventilatory SupportNoninvasive VentilationRespiratory Distress Syndrome, NewbornBronchopulmonary DysplasiaHumansInfant, NewbornRandomized Controlled Trials as TopicMeta-analysisNasal continuous positive airway pressureNon-invasive neurally adjusted ventilatory assistPremature infants

Identifiers

PMID40618138
PMCPMC12228326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.