Evidence map›Paper›PMID 40618130›Full record

ArticleAlzheimer's research & therapy2025

Prospective evaluation of plasma pTau

Javier Arranz, Rosa Ferrer, Nuole Zhu, Sara Rubio-Guerra, Íñigo Rodríguez-Baz, José Enrique Arriola-Infante, Lucía Maure-Blesa, Jesús Garcia-Castro, Judit Selma-González, María Carmona-Iragui and 7 more

Abstract read
In one paragraph

Article in Alzheimer's research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. A multiverse analysis of the logical memory test and plasma biomarkers of Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Javier Arranz *Sant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Rosa Ferrer *Servei de Bioquímica, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Nuole ZhuSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Sara Rubio-GuerraSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Íñigo Rodríguez-BazSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
José Enrique Arriola-InfanteCentro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Lucía Maure-BlesaSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Jesús Garcia-CastroSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Judit Selma-GonzálezSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
María Carmona-IraguiSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Isabel BarroetaSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Ignacio Illán-GalaSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Miguel Santos-SantosSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Juan ForteaSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Alberto LleóSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.
Mireia TondoServei de Bioquímica, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. mtondo@santpau.cat.
Daniel AlcoleaSant Pau Memory Unit, Department of Neurology, IR SANT PAU, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain. dalcolea@santpau.cat.

Funding

DS-ARC: A Remote Digital Cognitive Assessment for Down Syndrome-Associated Alzheimer's DiseaseR01AG081394 · NIA · WASHINGTON UNIVERSITY · PI Jason J Hassenstab · 2023 to 2026
$6.0M
The Role of Inflammation and NGF Dysfunction in the Evolution of Alzheimer Disease Pathology in Down Syndrome-RevisionRF1AG056850 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSCIGLIO, JORGE A, CUELLO, A CLAUDIO · 2018 to 2020
$5.9M
Clinical trials to prevent Alzheimer's Disease in Down SyndromeR61AG066543 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RAFII, MICHAEL S · 2019 to 2020
$5.6M
Tau pathology in Down syndrome and Alzheimer'sRF1AG061566 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, MARGITTAI, MARTIN · 2019 to 2019
$3.4M
Sleep and Temperature Disturbance as risk factors for Alzheimer's Disease in Down Syndrome: a Longitudinal StudyRF1AG080769 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BLESSING, ESTHER MARIAN, FORTEA, JUAN · 2023 to 2023
$1.9M
Biological Correlates of Alzheimer in Down Syndrome.R21AG056974 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER · 2017 to 2018
$414k
Alzheimer's Association AARG-22-973966CIBERNED program Program 1, Alzheimer DiseaseFondo Investigaciones Sanitario (FIS), Instituto de Salud Carlos III PI21/00791, PI14/01126, PI17/01019, PI20/01473, PI13/01532, PI16/01825, PI18/00335, PI22/00785, PI19/00882, PI18/00435, PI21/00791, PI22/00611, INT19/00016, INT23/00048, PI17/01896, PI24/00598 and AC19/00103Fundació la Marató de TV3 20141210, 044412 and 20142610Fundación Tatiana Pérez de Guzmán el Bueno IIBSP-DOW-2020-151Generalitat de Catalunya 2017-SGR-547, SLT006/17/125, SLT006/17/119, SLT002/16/408Global Brain Health Institute GBHI_ALZ-18-543740Horizon 2020-Research and Innovation Framework Programme from the European Union H2020-SC1-BHC-2018-2020Instituto de Salud Carlos III (Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España) INT21/00073, PI20/01473 and PI23/01786Instituto de Salud Carlos III through the Río Hortega Fellowship CM21/00243Instituto de Salud Carlos III through the Río Hortega Fellowship CM22/00052Instituto de Salud Carlos III through the Río Hortega Fellowship CM22/00219Instituto de Salud Carlos III through the Río Hortega Fellowship CM23/00176Instituto de Salud Carlos III through the Río Hortega Fellowship CM23/00291National Institutes of Health grants R01 AG056850; R21 AG056974, R01 AG061566, R01 AG081394 and R61AG066543 and 1RF1AG080769-01National Institutes of Health (NIA ) 1R01AG056850-01A1; R21AG056974; and R01AG061566NIA NIH HHS R01 AG081394NIA NIH HHS R21 AG056974NIA NIH HHS R61 AG066543NIA NIH HHS RF1 AG056850NIA NIH HHS RF1 AG061566NIA NIH HHS RF1 AG080769Societat Catalana de Neurologia Premi Beca Fundació SCN 2020
6 · The paper itself

Abstract

backgroundKnowledge on the effect of analytical variability and storage conditions are essential for the successful implementation of plasma pTau

aimsTo investigate the performance of plasma pTau

methodsWe prospectively measured pTau

resultsWe included 280 participants, divided into two groups: those with (n = 109) and without CSF data (n = 171). Among the subset with CSF, 48% were A + , with a plasma pTau

conclusionsThe robust stability and low lot-to-lot variability of plasma pTau

Indexed as

Alzheimer Diseasetau ProteinsAgedAged, 80 and overBiomarkersFemaleHumansMaleMiddle AgedProspective StudiesTertiary Care CentersBiomarkersMAPT protein, humantau ProteinsAlzheimerAmyloidBiomarkersBloodPlasmaStabilityTau

Identifiers

PMID40618130
PMCPMC12228402

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.