SynthesisSystematic reviews2025
HPV-16 lineages among women in Africa: a systematic review with meta-analysis.
Synthesis in Systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundInfection with high-risk human papillomavirus type 16 (HPV-16) is associated with cervical oncogenesis. The prevalence of HPV-16 lineages has not been well investigated in Africa. There is a lack of comprehensive epidemiological data on the distribution and oncogenic potential of the different HPV-16 lineages and sub-lineages in these populations. Through systematic review and meta-analysis, we aimed to determine the prevalence of HPV-16 lineages among women in Africa between 1997 and 2023.
methodEight databases were searched, and studies that identified HPV-16 positive women with distinct HPV-16 lineages, and those that clearly defined an African population, were included. The eight databases include PubMed, PubMed Central, BVS, Embase, Cochrane Library, Scopus, Web of Science, and EBSCOhost. This protocol is registered in PROSPERO (CRD42023437748) and followed the PRISMA guidelines.
resultsOut of the 2698 studies that were screened, 12 studies met the inclusion criteria and were included in the systematic review and meta-analysis. Analysis of these 12 studies identified yielded 1209 HPV-16-positive samples based on distinct diagnostic tests. These samples were classified as lineage A (n = 556), lineage C (n = 278), lineage B (n = 235), and lineage D (n = 140). Overall, lineage A variants were found in 11 studies (556 samples), establishing an overall prevalence of 58% (95% CI: 0.31-0.80; I
conclusionWomen in Africa exhibit a varied distribution of the four HPV-16 lineages. The high prevalence of HPV-16 lineage A in the entire population calls for developing targeted interventions to maximize impact and effectiveness. Future studies that are standardized and include defined geographic region, cytological details, and individual patient data should be conducted to enhance robust findings.
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