SynthesisBMC oral health2025
Evaluating the risk factors for complications of patients with oral and maxillofacial space infections: a systematic review and meta-analysis.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Outcomes of Adjunctive Corticosteroid Therapy Versus Standard Treatment Alone in Patients With Bacterial Facial Infections: A Systematic Review and Meta-Analysis.Clinical and experimental dental research · 2026Pooled it
- Article
- Prevalence and Associated Factors of Odontogenic Maxillofacial Space Infections Among Adult Patients at Hawassa University Comprehensive Specialized Hospital, Ethiopia: A Retrospective Cross-Sectional Study (2023-2025).Health science reports · 2026Article
- Risk factors for the emergence of multidrug-resistant bacteria in patients with head and neck infections: a retrospective analysis.Frontiers in oral health · 2026Article
- Analysis of pathogenic bacteria of oral and maxillofacial space infection and the effect of vacuum sealing drainage treatment.American journal of translational research · 2026Article
- Segmental airway volume as a predictive indicator of postoperative extubation timing in patients with oral and maxillofacial space infections: a retrospective analysis.BMC oral health · 2025Article
- Orbital and Maxillofacial Soft Tissue Infection Caused by Methicillin-ResistantCase reports in medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveThis study sought to perform a meta-analysis of the risk factors for the complications of oral and maxillofacial space infections (OMSI), aiming to provide insights for identifying cases at elevated risk and facilitating the further clinical prevention strategies.
methodsA comprehensive search of international (PubMed, Web of Science, Cochrane Library and CTdatabase) and Chinese (CNKI, Wanfang and VIP) databases was conducted through August 2024. The identified literature was assessed for quality, and meta-analysis was conducted using RevMan 5.0 software.
resultsA total of 12 studies were included, comprising 2,205 participants, among whom 417 experienced complications, yielding a complication rate of 18.91%. Meta-analysis identified the following as significant risk factors for OMSI-associated complications: age [odds ratio(OR): 1.59; 95% confidence interval(CI): 1.33-1.90], body temperature upon admission (OR: 2.97; 95% CI: 2.03-4.33), diabetes mellitus (OR: 2.70; 95% CI: 2.03-3.60), multiple space infections (OR: 2.90; 95% CI: 1.98-4.25), white blood cell (WBC) count (OR: 1.86; 95% CI: 1.48-2.35), neutrophil (NEUT) count (OR: 2.50; 95% CI: 1.60-3.93), and C-reactive protein (CRP) level (OR: 1.01; 95% CI: 1.00-1.01).
conclusionThe incidence of OMSI-associated complications is high. Independent risk factors include advanced age, elevated body temperature on admission, diabetes mellitus, involvement of multiple anatomical spaces, and increased levels of WBC, NEUT, and CRP. These factors may exacerbate infection severity, amplifying the risks of complications such as mediastinitis or sepsis. Therefore, it is crucial to closely monitor patients with these risk factors and implement early interventions to attenuate the incidence of OMSI-associated complications and enhance patient outcomes. While our findings provide valuable insights into risk factors for OMSI-related complications, several limitations-including the predominance of retrospective study designs, heterogeneity in diagnostic criteria and biomarker thresholds-may affect generalizability. Future large-scale and high-quality studies are needed to further validate these findings. CLINICAL TRIAL NUMBER: Not applicable.
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