ArticleBMC cardiovascular disorders2025
Serum vitamin E and cardiovascular diseases risk: a J-shaped association in a large cross-sectional study.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Integration of cAMP and TRPV4 Signaling to Optimize Collagen Remodeling for Management of Fibrosis.Cells · 2025Review
- Red cell distribution width predicts early kidney injury: A NHANES cross-sectional study.Open medicine (Warsaw, Poland) · 2025Article
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Authors and funding
7 authors.
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Abstract
objectiveCardiovascular diseases (CVDs) has been identified as a primary cause of mortality on a global scale. The present study was conducted with the objective of investigating the association between serum vitamin E levels and the risk of developing CVDs, with the aim of identifying potential risk thresholds.
methodsUsing National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2002, we included 3,516 adult participants. Serum vitamin E concentrations were measured by high-performance liquid chromatography, and CVDs status was assessed through medical questionnaires and interviews. Multivariable logistic regression and segmented linear models analyzed the association between serum vitamin E and CVDs risk.
resultsA J-shaped relationship between serum vitamin E and CVDs risk was observed. Segmented linear regression revealed a nonlinear association between vitamin E concentration and CVDs incidence. At low concentrations (below 85.24 µg/dL), although the OR suggested a potential protective trend (OR: 0.968, 95% CI: 0.926-1.011), this association did not reach statistical significance (P = 0.1422), indicating no conclusive evidence of risk reduction. Beyond this threshold, CVDs risk significantly increased (OR: 1.056, 95% CI: 1.003-1.112, P = 0.0377). Notably, the high-concentration group demonstrated a substantially elevated CVDs risk, with a 4.18-fold increase (OR: 4.18, 95% CI: 2.84-6.16, P < 0.0001).
conclusionMaintaining serum vitamin E levels within an optimal range is crucial for reducing CVDs risk. The study reveals the complex nonlinear relationship between vitamin E concentration and disease risk, providing important insights for clinical practice and public health strategies.
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