Evidence map›Paper›PMID 40618055›Full record

ArticleBMC genomics2025

Sex-biased expression of sex-linked transcripts in spiny frogs with homomorphic sex chromosomes.

Yu Xiao, Yun Xia, Xiaomao Zeng

Abstract read
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu XiaoChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610213, China.
Yun XiaChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610213, China. xiayun@cib.ac.cn.
Xiaomao ZengChengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610213, China. zengxm@cib.ac.cn.

Funding

the National Natural Science Foundation of China No. 32170419the National Natural Science Foundation of China No. 32270448
6 · The paper itself

Abstract

backgroundThe accumulation of sexually antagonistic mutations on chromosomes has been favored in driving the evolution of sex chromosomes. However, empirical evidence has been limited to species with heteromorphic sex chromosomes, where the patterns of gene expression on sex chromosomes differ drastically from those on autosomes. It is little known if the sexualization of gene expression would have started on homomorphic sex chromosomes.

resultsTo investigate the evolutionary patterns of sex-biased expression, we examined four species of spiny frogs, using high-throughput RNA sequencing for gonads and sex-specific tissues. We find little support for both the enrichment of sex-linked genes and the excess of sex-linked gene expression. Additionally, there is no evidence supporting for sex-biased gene expression near the candidate sex-determining locus. We find no significant accumulation of sex-biased genes on sex chromosomes. Further, the homomorphic sex chromosomes do not show evidence of a faster rate of evolution.

conclusionsThe sexualization of sex chromosomes in species with homomorphic sex chromosomes may not be as indispensable as hypothesized.

Indexed as

AnuraSex ChromosomesAnimalsEvolution, MolecularFemaleMaleSex Determination ProcessesEvolutionary rateFaster-X effectGene expressionSex biasSexualizationSexually antagonistic genes

Identifiers

PMID40618055
PMCPMC12229019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.