ArticleBMC geriatrics2025
Sarcopenia as a predictor of mortality in centenarians: insights from a prospective cohort study.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sarcopenia in idiopathic pulmonary fibrosis: an updated systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Health status characteristics and aging determinants of centenarians in Colombia: a real-life expanded cohort profile description.BMC geriatrics · 2026Article
- Testosterone modifies U-Shaped association of eGFR with all-cause mortality in Chinese female centenarians: a prospective cohort study.Reproductive biology and endocrinology : RB&E · 2026Article
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6 authors.
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Abstract
BACKGROUND &
aimsCentenarians represent a unique population where predictors of mortality are understudied.Studies have shown that sarcopenia is associated with adverse health outcomes and premature death in elderly patients. The aim of our study was to explore the association between sarcopenia and centenarian mortality.
methodsOur study is a prospective cohort study. Muscle mass was measured using bioelectrical impedance analysis (BIA), and the relative skeletal muscle index (RSMI) was adjusted for height to reduce individual differences. Sarcopenia is defined according to the Asian Sarcopenia Working Group’s (AWGS)2019 updated diagnostic criteria for sarcopenia, it introduces the concept of “possible sarcopenia”, defined as the presence of only low muscular strength or low physical performance, specifically for primary health care or community health promotion to enable earlier lifestyle interventions. The survival time of centenarians with and without sarcopenia was compared using the Kaplan-Meier method, and the hazard ratio (HR) and 95% confidence interval (95% CI) for mortality were determined using the Cox proportional hazards regression model.
resultsA total of 98 centenarians were included in this study, with an average age of (102.2 ± 1.8) years. The prevalence of sarcopenia was 20.4%. The Cox proportional hazards model analysis showed that after adjusting for confounding factors, the risk of death was increased by 3.64 times in the sarcopenia group (HR = 4.64, 95% CI: 2.48–8.66).
conclusionSarcopenia can serves as a significant predictor of long-term mortality in centenarians and functions as an important independent predictor.
trial registrationThe trial was registered at the Chinese Clinical Trial Center on 17-01-2019. Trial registration numbers 2018 − 463; ChiCTR1900020754.
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