ArticleJournal of cardiovascular translational research2025
Identification of Prognostic Factors for Sepsis or Septic Shock Patients with Cardiac Dysfunction.
Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Myocardial markers and inflammatory factors have been identified as risk factors for the development of sepsis-induced cardiac dysfunction (SIC), the prognostic significance and clinical utility of utilizing a multi-index combined prognostic approach remain uncertain. Our objective was to establish a "risk score" utilizing clinical indexes to provide short-term prognostic insight for individuals with SIC. Utilizing Lasso regression and COX regression analysis, we identified a history of diabetes, CRP, and NT-proBNP on day 3 as independent risk factors for 28-day mortality in SIC patients. Specifically, the Cox regression analysis identified a hazard ratio of 24.74 (95% CI: 5.90-103.71) for the high-risk group. The prognostic thresholds for CRP and NT-proBNP were determined to be 83.3 mg/L and 1720.7 ng/L, respectively. In conclusion, a "risk score" predictive model incorporating diabetes history, CRP, and NT-proBNP was developed to assess 28-day mortality in patients with SIC.
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