Evidence map›Paper›PMID 40618003›Full record

ArticleApoptosis : an international journal on programmed cell death2025

Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy.

Ziwen Qiao, Guangmin Zhang, Xin Chen, Yuefa Zhang, Sudan Zhang, Xiuheng Qin, Ammara Sohail, Xiaohui Xu, Jiane Liu, Baoqin Han and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ziwen Qiao *Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, 266071, Shandong, China.
Guangmin Zhang *Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, 266071, Shandong, China.
Xin ChenGraduate School, Shandong First Medical University, Jinan, 250000, Shandong, China.
Yuefa ZhangInternational Joint Laboratory of Medicinal Food R&D and Health Products Creation/Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology (Shandong Academy of Sciences), Heze, 274000, Shandong, China.
Sudan ZhangDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, 266071, Shandong, China.
Xiuheng QinInternational Joint Laboratory of Medicinal Food R&D and Health Products Creation/Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology (Shandong Academy of Sciences), Heze, 274000, Shandong, China.
Ammara SohailDepartment of Chemistry, University of Okara, Okara, 56300, Pakistan.
Xiaohui XuDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, 266071, Shandong, China.
Jiane LiuDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, 266071, Shandong, China.
Baoqin HanCollege of Marine Life Sciences, Ocean University of China, Shandong, 266000, China.
Daijie WangInternational Joint Laboratory of Medicinal Food R&D and Health Products Creation/Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology (Shandong Academy of Sciences), Heze, 274000, Shandong, China. wangdaijie@qlu.edu.cn.
Xiangyan ZhangDepartment of Pathology, the Affiliated Hospital of Qingdao University, Qingdao, 266071, Shandong, China. 2019010055@qdu.edu.cn.
Zheng WangDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, 266071, Shandong, China. zheng.wang@qdu.edu.cn.ORCID 0000-0003-4471-5983

Funding

Shandong Provincial Natural Science Foundation Major Basic Research Project ZR2022ZD21
6 · The paper itself

Abstract

Aspirin, widely recognized for its anti-inflammatory and cardioprotective effects, has also shown potential as a cancer therapeutic. However, its clinical application is hindered by severe adverse effects. Here, we explore 6-O-Carboxymethyl-N-Acetylglucosamine (CM-NAG) a novel derivative of N-acetylglucosamine, designed to mimic the structural and functional properties of aspirin. CM-NAG significantly inhibits the viability of both colorectal and pancreatic cancer cells. In colorectal cancer cells, CM-NAG also suppressed migration and invasion and induced apoptosis more effectively than aspirin. Mechanistically, CM-NAG upregulated phosphoenolpyruvate carboxykinase 2 (PCK2), a key regulator of gluconeogenesis in colorectal cancer cells. In a xenograft model, CM-NAG reduced tumor size and improved histopathological outcomes, while showing no significant toxicity in major organs. The expression of PCK2 in CRC tissues was significantly lower than in cancer-adjacent tissues, according immunohistochemistry analysis. Clinical analysis revealed high PCK2 expression in colorectal cancer tissues correlates with better disease-free survival, supporting PCK2 as a promising therapeutic target. These findings suggest that CM-NAG may represent a next-generation antitumor agent with enhanced efficacy and safety compared to aspirin, offering new prospects for cancer treatment.

Indexed as

AcetylglucosamineAntineoplastic AgentsAspirinColorectal NeoplasmsPancreatic NeoplasmsAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationCell SurvivalFemaleHumansMaleMiceMice, Inbred BALB CAcetylglucosamineAntineoplastic AgentsAspirinAspirinCarboxymethylationColorectal cancerN-acetylglucosaminePhosphoenolpyruvate carboxykinase 2

Identifiers

PMID40618003

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.