Evidence map›Paper›PMID 40617961›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2025

Association of low hospital birth volume and adverse short-term outcomes for neonates treated with therapeutic hypothermia in rural states.

Alexa K Craig, Anya Cutler, Jay Kerecman, Misty Melendi, Leah Marie Seften, Matthew Ryzewski, Allison Zanno, Deirdre O'Reilly

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Alexa K CraigDivision of Pediatric Neurology, Department of Pediatrics, Barbara Bush Children's Hospital at Maine Medical Center, Portland, ME, USA. alexa.craig@mainehealth.org.ORCID http://orcid.org/0000-0002-6477-3390
Anya CutlerCenter for Interdisciplinary Population and Health Research, Maine Medical Center, Portland, ME, USA.ORCID http://orcid.org/0000-0003-3439-9606
Jay KerecmanDivision of Neonatology, Department of Pediatrics, Northern Light Eastern Maine Medical Center, Bangor, ME, USA.
Misty MelendiDivision of Neonatology, Department of Pediatrics, Barbara Bush Children's Hospital at Maine Medical Center, Portland, ME, USA.ORCID http://orcid.org/0000-0003-4171-650X
Leah Marie SeftenDepartment of Pediatrics, Barbara Bush Children's Hospital at Maine Medical Center, Portland, ME, USA.
Matthew RyzewskiDivision of Neonatology, Department of Pediatrics, Elliot Hospital, Manchester, NH, USA.
Allison ZannoDivision of Neonatology, Department of Pediatrics, Barbara Bush Children's Hospital at Maine Medical Center, Portland, ME, USA.
Deirdre O'ReillyDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Larner College of Medicine and University of Vermont Medical Center, Burlington, VT, USA.

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Brenda Morissette Joly · 2017 to 2026
$51.6M
Telemedicine to Reduce Disparities in the Identification and Treatment of Neonatal EncephalopathyP20GM139745 · NIGMS · MAINEHEALTH · PI Allison Elizabeth Zanno · 2021 to 2026
$19.2M
NIGMS NIH HHS P20 GM139745NIGMS NIH HHS U54 GM115516U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 1P20GM139745-01
6 · The paper itself

Abstract

objectiveWe hypothesized that outborn neonates in three rural states would have more frequent adverse short-term outcomes following therapeutic hypothermia (TH). STUDY

designMulticenter retrospective study comparing outcomes for low (<500 births/year), medium (501-1500 births/year), and high (>1500 births/year) birth volume hospitals in Northern New England. Multivariable logistic regression assessed the combined outcome of death/severe gray matter injury on MRI, controlling for encephalopathy severity and time to initiation of TH.

resultsDeath occurred for 35/531 neonates: 15/120 (12%) low, 7/193 (4%) medium, and 13/218 (6%) for high birth volume hospitals (p = 0.008). Severe gray matter injury occurred in 8%, 6% and 7% of low, medium, and high birth volume hospitals, respectively (p = 0.7). Odds of the combined outcome were 4.3-fold higher in low versus high volume hospitals (95% CI = 1.6, 12.1, p = 0.004).

conclusionNeonates born in low volume birth hospitals had significantly higher odds of death following treatment with TH.

Indexed as

Hospitals, Low-VolumeHypothermia, InducedHypoxia-Ischemia, BrainFemaleHospitals, High-VolumeHumansInfant, NewbornLogistic ModelsMagnetic Resonance ImagingMaleNew EnglandRetrospective Studies

Identifiers

PMID40617961
PMCPMC12967301

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.