Evidence map›Paper›PMID 40617958›Full record

ArticleScientific reports2025

Sex differences in placental structure and gene expression in ICR mice during embryonic development.

Xinyi Man, Noriyoshi Usui, Miyuki Doi, Shoichi Shimada

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xinyi ManDepartment of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan.
Noriyoshi UsuiDepartment of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan. usui@anat1.med.osaka-u.ac.jp.
Miyuki DoiDepartment of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan.
Shoichi ShimadaDepartment of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan.

Funding

Japan Science and Technology Agency JPMJSP2138Japan Society for the Promotion of Science 23H02837Japan Society for the Promotion of Science 23K14443
6 · The paper itself

Abstract

The placenta is a vital organ for fetal development, providing structural support and mediating both nutrient exchange and maternal-fetal immune interactions. However, there are many aspects of murine placental development, which are used as a model organism, that are not fully understood compared to humans. In this study, we examined sex differences in placental development in ICR mice, a commonly used outbred strain, by analyzing the junctional zone (JZ) and labyrinth (LAB) from embryonic day (E) 8.5 to E18.5. At E14.5, the JZ area and its proportion relative to the total placental area (JZ + LAB) were significantly larger in females than in males. Consistently, expression levels of JZ-associated genes were also higher in female placentas at this stage. In contrast, such sex differences in placental morphology and gene expression were not observed in C57BL/6J mice, suggesting that observed features are unique to the ICR strain. Collectively, our findings demonstrate a female-biased expansion of the JZ in ICR mice at mid-gestation and underscore the presence of strain-specific patterns in sex-dependent placental development.

Indexed as

Embryonic DevelopmentGene Expression Regulation, DevelopmentalPlacentaPlacentationSex CharacteristicsAnimalsFemaleMaleMiceMice, Inbred C57BLMice, Inbred ICRPregnancyDeciduaJunctional zoneLabyrinthPlacental developmentSex differenceTrophoblast

Identifiers

PMID40617958
PMCPMC12228721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.