SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025
Depression and anxiety in empty nose syndrome: A systematic review and Meta-analysis.
Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Cluster Analysis of Patients With Empty Nose Syndrome and Its Relation to Surgical Outcome.The Laryngoscope · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmpty nose syndrome (ENS) is a condition characterized by a persistent feeling of nasal obstruction despite having a patent nasal airway. This study aims to understand prevalence of depression and anxiety in patients with ENS and the impact of augmentation procedures on psychological symptoms.
methodsThe literature was searched in accordance with PRISMA guidelines. Outcome measures were collected for mental health prevalences and patient-related outcome measures (PROMs).
resultsOf 1056 abstracts identified, 11 studies (N = 401 patients) were included. Among patients with ENS, prevalences of depression and anxiety were 76.6% (95%CI: 61.0-89.1) and 77.0% (95% CI: 49.9-95.5). The prevalence of depression in patients with ENS was significantly increased compared to that of patients with chronic rhinosinusitis (CRS) (RR: 2.8 [95%CI: 1.5-5.2], p = 0.001) in studies which compared both conditions. In patients who underwent augmentation, Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 showed no significant improvement at 6-month follow-up (5.39 [95%CI: -0.7-11.5], p = 0.08; 5.45 [95%CI: -2.8-13.7], p = 0.20) while Beck Depression Inventory-II and Beck Anxiety Inventory showed significant improvement at 6-month follow-up (11.94 [95%CI: 8.7-15.2], p < 0.00001; 10.83 [95%CI: 7.7-14.], p < 0.0001).
conclusionsDepression and anxiety are common among patients with ENS, with a possible increased prevalence of depression in patients with ENS compared to those with CRS. Patients with ENS demonstrated inconsistent improvement in depression and anxiety scores following augmentation procedures depending on the PROMs utilized. As patients with ENS often have mental health comorbidities, further research should investigate whether anxiety and depression are true sequelae of ENS or factors contributing to its development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.