ArticleNPJ microgravity2025
Phenotypic, transcriptomic and metabolomic changes in Klebsiella pneumoniae after long term exposure to simulated microgravity.
Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Klebsiella pneumoniae (K. pneumoniae) has been detected on space stations. Microgravity is a key environmental factor in spaceflight, however, research on the phenotypic, genetic, and metabolic changes K. pneumoniae undergoes due to long-term exposure to microgravity is still limited. K. pneumoniae was cultured under normal gravity (NG) and simulated microgravity (SMG) for 56 days, showing phenotypic changes like slower growth, larger and rounder cell morphology, and increased biofilm formation in SMG. RNA sequencing analysis revealed that the DEGs were associated primarily with metabolic and growth pathways, including those involved in biofilm formation. Metabolomic analysis revealed changes in the activity of the phenylalanine metabolic pathway, which was the most significantly enriched pathway, due to the interaction between the mhp gene cluster and related DEMs. Co-expression network analysis revealed intricate relationships between DEGs and DEMs, notably in arginine and proline metabolism. This study provides insights into K. pneumoniae's response mechanisms to microgravity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.