Evidence map›Paper›PMID 40617804›Full record

ArticleCell death & disease2025

Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice.

Jantina A Manning, Shilpanjali Jesudason, Paul A B Moretti, Stuart M Pitson, Angela S Y Chou, Meriam Shabbar, Sonia Saad, Carol Pollock, Sharad Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jantina A ManningCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia. jantina.manning@unisa.edu.au.ORCID http://orcid.org/0000-0001-9142-6135
Shilpanjali JesudasonCentral Northern Adelaide Renal and Transplantation Service (CNARTS), Royal Adelaide Hospital, Adelaide, SA, Australia.
Paul A B MorettiCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.
Stuart M PitsonCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-9527-2740
Angela S Y ChouNSW Health Pathology, Royal North Shore Hospital, The University of Sydney, Sydney, NSW, Australia.
Meriam ShabbarCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0001-9954-7222
Sonia SaadKolling Institute of Medical Research, Royal North Shore Hospital and The University of Sydney, Sydney, NSW, Australia.
Carol PollockKolling Institute of Medical Research, Royal North Shore Hospital and The University of Sydney, Sydney, NSW, Australia.
Sharad KumarCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0001-7126-9814

Funding

Diabetes Australia Y23G-MANJ
6 · The paper itself

Abstract

NEDD4-2, a ubiquitin ligase, regulates a number of ion channels and transporters by promoting their ubiquitination, internalisation and degradation, thereby affecting many signalling and physiological outcomes. Loss of this gene in mice results in tubular cell death and a chronic kidney disease (CKD)-like phenotype due to aberrant Na

Indexed as

Diabetes Mellitus, ExperimentalDiabetic NephropathiesGlycemic ControlKidneyNedd4 Ubiquitin Protein LigasesAnimalsDisease Models, AnimalEpithelial Sodium ChannelsHumansMaleMiceMice, Inbred C57BLMice, KnockoutEpithelial Sodium ChannelsNedd4l protein, mouseNedd4 Ubiquitin Protein Ligases

Identifiers

PMID40617804
PMCPMC12228766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.