ArticleTranslational psychiatry2025
7-Tesla ultra-high field MRI of the parahippocampal cortex reveals evidence of common neurobiological mechanisms of major depressive disorder and neurotic personality traits.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Trait-relevant movies amplify neuroticism-associated brain responses.Communications psychology · 2026Article
- The impact of hearing loss on tinnitus-related brain reorganization: evidence from multimodal resting-state functional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- Accelerated TMS is associated with changes of subgenual cingulate-default mode network coupling in depression: an observational 7 Tesla fMRI study.European archives of psychiatry and clinical neuroscience · 2026Article
- History of childhood trauma enhances the detrimental effects of recent stressors on brain structure and function in major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
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Abstract
The parahippocampal cortex (PHC) is a highly interconnected region within the medial temporal lobe (MTL) and is essential in memory, emotion and cognition. According to the cognitive model of depression, dysfunctions in these processes constitute the pathophysiological foundation of major depressive disorder (MDD). Research suggests that human personality, and neuroticism in particular, plays an important role in the development and disease progression of MDD. Furthermore, extensive neuroimaging evidence indicates that neuroticism and depression share overlapping structural and functional correlates, potentially including the PHC. In a matched sample of 86 adults (43 MDD patients, 43 control participants, mean age 31.4 years, range 18-61 years, 40 female), PHC thickness was measured using structural MRI at an ultra-high field strength of 7 T and compared to the level of neuroticism as measured by the NEO-FFI scale. MDD patients exhibited significantly lower left hemispheric PHC thickness compared to healthy controls (p
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