ArticleTranslational psychiatry2025
Genetic, psychological, and environmental factors are uniquely associated with onset of alcohol use in the adolescent brain cognitive development (ABCD) study.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Developmental Timing of Alcohol Initiation as a Marker of Adult Clinical Complexity in Alcohol Use Disorder: A Cross-Sectional Study.Medical sciences (Basel, Switzerland) · 2026Article
- From adolescence to Alzheimer's: a neurodevelopmental lifespan model of cognitive vulnerability.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- From school climate to brain development: What the ABCD study reveals about the educational context of adolescence.Developmental cognitive neuroscience · 2026Review
- The ABCD Study at 10: The NIH perspective on progress, impact, and the road ahead.Developmental cognitive neuroscience · 2026Article
- Risk Perception and Susceptibility to Peer Influence Predict Substance Use in Early Adolescence: Findings From the ABCD Study.Journal of studies on alcohol and drugs · 2026Article
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
- Individual, interpersonal, organizational, and community contexts: factors associated with alcohol consumption among Brazilian adolescents.BMC pediatrics · 2026Article
- Alcoholics anonymous and recovery in Türkiye: A qualitative study in the context of Social Identity Theory.The British journal of social psychology · 2026Article
- Perceived partner substance use, genetic predispositions, and their associations with problematic alcohol use, emotional well-being, and relationship quality.Psychological medicine · 2026Article
- Disruption ofiScience · 2026Article
- Self-reported impulsivity, task-based inhibitory control, and early sipping behaviors as longitudinal predictors of adolescent alcohol use and problems in the ABCD Study.medRxiv : the preprint server for health sciences · 2026Article
- Learning Mechanisms in Alcohol Use Disorders.Addiction biology · 2026Review
- Article
- Hillclimb-Causal Inference: a data-driven approach to identify causal pathways among parental behaviors, genetic risk, and externalizing behaviors in children.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Youth Correlates of Genetic Liability to Substance Use Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Genetic influences for distinct impulsivity domains are differentially associated with early substance use initiation: Results from the ABCD Study.Psychological medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
Alcohol use during adolescence poses a significant public health problem due to its potential long-term consequences on both physical and mental health and increased risk for developing substance use disorders later in life. Both individual (e.g., genetic liability, neural functioning, personality features) and environmental (e.g., parenting, school environment) features play an important role in accelerating or buffering the progression of early alcohol consumption. This study used data from the Adolescent Brain Cognitive Development (ABCD) study (Release 5.1; N = 11,868) to provide a comprehensive examination of how genetic, neural, trait, and environmental factors are associated with risk for first sip of alcohol, first full drink, and the progression from first sip to full drink, both independently and uniquely. Cox proportional hazard models were used to examine the univariable associations between theoretically relevant genetic, neural, trait, and environmental variables and early alcohol use. Then, stepwise model-fitting was used to determine which indicators were uniquely associated with alcohol outcomes. Risk for early alcohol use was distributed across multiple domains highlighting the unique information provided by genetic, trait, and environmental variables. Results also indicated the importance of both environmental and genetic factors on time to first sip of alcohol, but that time to first full drink and the progression from sip to drink was most associated with genetic and trait factors rather than broad environmental influences. These findings highlight both potential etiological pathways driving early alcohol use as well as phenotypic and environmental process that can be targeted for early intervention efforts.
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