Evidence map›Paper›PMID 40617757›Full record

ArticleTrends in genetics : TIG2025

Psychiatric disorders: teasing apart genetic similarities and differences.

Jiayi Xu, Laura M Huckins

Abstract read
In one paragraph

Article in Trends in genetics : TIG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jiayi XuDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Genomics Preprint Club, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: jiayi.xu@yale.edu.
Laura M HuckinsDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Funding

High-throughput in vivo and in vitro functional and multi-omics screens of neuropsychiatric and neurodevelopmental disorder risk genesRM1MH132648 · NIMH · YALE UNIVERSITY · PI Kristen Jennifer Brennand, Rong Fan · 2023 to 2026
$5.6M
1/3 Eating Disorders Genetics Initiative 2 (EDGI2)R01MH136149 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CYNTHIA M BULIK, Laura Marianne Huckins · 2024 to 2026
$5.1M
Modeling the interaction of physiological and environmental stressors on common variants to psychiatric traitsR01ES033630 · NIEHS · YALE UNIVERSITY · PI Kristen Jennifer Brennand · 2022 to 2026
$4.6M
Cross-Population Working Group on Genes and Environment in Major Depression (POP-GEM): Advancing the Understating of Etiology through DiversityR01MH125938 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Roseann Elizabeth Peterson · 2022 to 2026
$4.2M
Predicting the multi-omic impact of psychiatric GWAS associationsR01MH118278 · NIMH · YALE UNIVERSITY · PI HUCKINS, LAURA MARIANNE · 2019 to 2023
$3.6M
3/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124839 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANDREASSEN, OLE A, HUCKINS, LAURA MARIANNE · 2021 to 2025
$2.0M
NIEHS NIH HHS R01 ES033630NIMH NIH HHS R01 MH118278NIMH NIH HHS R01 MH124839NIMH NIH HHS R01 MH125938NIMH NIH HHS R01 MH136149NIMH NIH HHS RM1 MH132648
6 · The paper itself

Abstract

Given the high comorbidity between psychiatric disorders, previous studies have focused on genetic factors shared across the disorders. In a recent preprint, Grotzinger et al. comprehensively investigated shared and disorder-specific genetic factors across 14 neuropsychiatric disorders. Here, we discuss how this investigation could improve psychiatric nosology and therapeutic development.

Indexed as

Genetic Predisposition to DiseaseMental DisordersHumansgenomicsnosologypleiotropypsychiatric disordersspecificitytherapeutic development

Identifiers

PMID40617757
PMCPMC12282334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.