ArticleBMJ paediatrics open2025
Intensity of perinatal care for extreme preterm births and neurodevelopmental outcomes at age 5½: the EPIPAGE-2 cohort study.
Article in BMJ paediatrics open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the impact of intensity of perinatal ('survival-focused') care on outcomes at 5½ years for two groups of survivors: those born at 24-26 and at 27-28 weeks of gestation.
designProspective, population-based national cohort.
settingFrance, 2011. PATIENTS: Children surviving to 5½ years who were born at <29 weeks gestation.
interventionsIntensity of perinatal care, defined at the hospital level, categorised into three based on the ratio of babies of 24-25 weeks of gestation admitted into neonatal intensive care to the number of fetuses alive at maternal admission to hospital subsequently delivered at 24-25 weeks gestation.
main outcome measuresNeurodevelopmental disability (NDD-none, mild, moderate or severe) comprising cognitive, behavioural, sensory and motor abilities.
resultsAmong 3217 births, 472 children born at 24-26 weeks and 633 born at 27-28 weeks survived. At 24-26 weeks, compared with children born in low-intensity hospitals, children born in high-intensity hospitals had the lowest levels of mild (33.9%) and moderate-severe (21.9%) NDD (ORs 0.42, 0.20-0.88 and 0.47, 0.20-1.12, respectively); no difference was found between hospitals of low and medium intensity. At 27-28 weeks of gestation, no differences were seen between hospitals of any intensity level (p=0.75).
conclusionsNo evidence was found to support concerns that survival-focused perinatal care is associated with increased long-term NDDs in children born extremely preterm or at a higher gestational age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.