Trial reportBiological psychiatry2026
Mapping Cerebellar Connectivity to Cognition in Psychosis: Convergent Evidence From Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation.
Trial report in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional brain abnormalities of cognitive impairments in schizophrenia indicating higher integration of working memory than other domains.Molecular psychiatry · 2026Pooled it
- Cerebellar dysconnectivity in schizophrenia spectrum: task-based functional connectivity analysis and cognitive stratification.Frontiers in psychiatry · 2026Article
- Cerebellar Connectivity Addresses Gaps in Cognitive Deficits and Negative Symptoms in Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Cerebellar-Prefrontal Connectivity Predicts Negative Symptom Severity Across the Psychosis Spectrum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Altered cortical-striatal circuits connectivity is associated with psychotic symptoms in patients with first-episode, drug-naïve early-onset schizophrenia.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundCerebellar dysfunction is strongly implicated in both cognitive impairments and psychosis, and the cognitive dysmetria hypothesis posits cognition as the intermediary in the pathway from cerebellar dysfunction to psychopathology. However, the nuanced cerebellum-behavior relationships in psychosis remain unclear. Establishing such a link is crucial to understand cerebellar mechanisms and to identify treatment targets for cognitive deficits in patients.
methodsWe studied 100 patients with early psychosis from the Human Connectome Project for Early Psychosis study. Connectome-based predictive modeling was conducted to probe cognitive functions most strongly predicted by cerebellar connectivity. Mediation analysis was performed to test for a possible mediating role of cognition between cerebellar connectivity and symptoms. To further support the causality of the findings, we also recruited 16 patients with psychosis for a 2-week randomized, sham-controlled cerebellar transcranial magnetic stimulation (TMS) trial.
resultsCerebellar connectivity significantly predicted 3 cognitive functions, namely verbal ability, working memory, and cognitive flexibility. Verbal ability fully mediated the relationship between cerebellar connectivity and negative symptoms, in particular alogia. While each cognitive function was predicted by a distinct cerebellar connectivity pattern, the left crus I/II appeared to be a common area with connectivity that consistently predicted all 3 functions. Stimulating this region via TMS was associated with significantly improved cognitive composite score and medium-to-large effects on scores for memory, verbal, and executive functions.
conclusionsThese findings suggest a potential causal pathway from cerebellar connectivity to domain-specific cognitive deficits and psychopathology in schizophrenia. They also point to the cerebellum as a potential target for the treatment of cognitive dysfunction in psychotic disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.