Evidence map›Paper›PMID 40617376›Full record

Trial reportThe journal of allergy and clinical immunology. In practice2025

AIRWEIGHS: A Randomized Controlled Trial of Air Cleaners in Normal Weight and Overweight/Obese Children With Asthma.

Anna Y Qiu, Emily P Brigham, Han Woo, Roger D Peng, Rachelle Koehl, Tianshi David Wu, Lesliam Quirós-Alcalá, Meghan F Davis, Nadia N Hansel, Kirsten Koehler and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of allergy and clinical immunology. In practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna Y QiuDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Emily P BrighamDivision of Respirology, University of British Columbia, Vancouver, BC, Canada; Legacy for Airway Health, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
Han WooDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Roger D PengDepartment of Statistics and Data Sciences, University of Texas at Austin, Austin, Texas.
Rachelle KoehlDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Tianshi David WuSection of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, Texas.
Lesliam Quirós-AlcaláDepartment of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Meghan F DavisDepartment of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Division of Infectious Diseases, Department of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, MD.
Nadia N HanselDepartment of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Kirsten KoehlerDepartment of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Meredith C McCormackDepartment of Environmental Health & Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: mmccor16@jhmi.edu.

Funding

Pilot Project ProgramP30ES032756 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 2022 to 2026
$6.0M
The role of obesity in biological responses to particulate matter in miceP50ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$4.8M
Translation CoreP2CES033415 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Kirsten Anne Koehler · 2022 to 2026
$4.8M
Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with AsthmaK23ES029105 · NIEHS · UNIVERSITY OF BRITISH COLUMBIA · PI BRIGHAM, EMILY · 2019 to 2022
$755k
Antimicrobial Agents and Asthma Morbidity among African American Children withAsthmaK01HL138124 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI QUIROS-ALCALA, LESLIAM · 2017 to 2021
$666k
Effects of pest and pet animal microbiota on child microbiota and asthma: a one health studyK01OD019918 · OD · JOHNS HOPKINS UNIVERSITY · PI DAVIS, MEGHAN F. · 2016 to 2020
$621k
NHLBI NIH HHS K01 HL138124NIEHS NIH HHS K23 ES029105NIEHS NIH HHS P2C ES033415NIEHS NIH HHS P30 ES032756NIEHS NIH HHS P50 ES018176NIH HHS K01 OD019918
6 · The paper itself

Abstract

backgroundOverweight and obesity are risk factors for increased asthma morbidity among children, and overweight/obese children with asthma may be more susceptible to air pollution.

objectiveTo test the hypothesis that there would be greater improvement in asthma from an air cleaner intervention to reduce indoor air pollution among overweight/obese children compared with normal weight children.

methodsAIRWEIGHS is a randomized, placebo-controlled air cleaner trial designed to reduce indoor air pollution and test the differential health impact among overweight/obese children versus normal weight children with asthma. Asthma outcomes and home air pollution were measured at baseline and 12 weeks after intervention. The primary outcome was maximum symptom days over 2 weeks, defined as the largest value of days of slowed activity, number of nights of waking, and days of coughing, wheezing, and chest tightness due to asthma. Secondary outcomes included asthma questionnaires, lung function, fractional exhaled nitric oxide, and exacerbations.

resultsA total of 164 children (aged 10.9 ± 2.5 years, 41% female, 85% Black, and 59% overweight/obese) were randomized to portable air cleaners with high-efficiency particulate air filters or identical devices without filters. Average baseline air pollutants (ultrafine particle [UFP]: 45.3 μm

conclusionAir cleaners effectively reduced indoor air pollution, but there was no observable benefit in asthma outcomes in children.

Indexed as

Air Pollution, IndoorAsthmaObesityOverweightPediatric ObesityAdolescentAir FiltersChildFemaleHumansMaleAir filterAir pollutantsAsthmaControlled clinical trialEnvironmentPediatric obesity

Identifiers

PMID40617376
PMCPMC13140095

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.