Mitochondrial curation for the next generation.

Gregory C Gundberg, Jeremy Nance

Abstract readReview

In one paragraph

Review in Current opinion in genetics & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Mitochondrial Remodeling, Cytoskeletal Dynamics, and Translational Control DuringBiology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gregory C GundbergCenter for Quantitative Cell Imaging, University of Wisconsin, Madison, WI, USA; Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI, USA; Cellular and Molecular Biology Graduate Program, University of Wisconsin, Madison, WI, USA. Electronic address: https://twitter.com/@g_gundberg.

Jeremy NanceCenter for Quantitative Cell Imaging, University of Wisconsin, Madison, WI, USA; Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI, USA. Electronic address: jfnance@wisc.edu.

Funding

The Role of Cell Interactions in Shaping DevelopmentR35GM118081 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Jeremy Nance · 2016 to 2026

$6.4M

NIGMS NIH HHS R35 GM118081

6 · The paper itself

Abstract

The mitochondrial genome (mtDNA) can accumulate deleterious mutations that lead to disease. Animals have evolved strategies to eliminate mtDNA mutations in the maternal germ line, increasing the likelihood that their progeny inherit healthy mitochondria. Here, we provide an overview of mitochondrial quality control in the germ line, focusing on recent findings in mammals, Drosophila, and C. elegans. We discuss three strategies for quality control: elimination of sperm mtDNA, which prevents transmission of paternal mtDNA to progeny; the genetic bottleneck, which reduces the effective number of mtDNAs in germ cells, potentially exposing mutations to selection; and purifying selection, which selects for healthier mtDNAs. Finally, we discuss outstanding questions in the field and technical advances needed to address them.

Indexed as

DNA, MitochondrialGenome, MitochondrialMitochondriaAnimalsCaenorhabditis elegansDrosophilaGerm CellsHumansMaleMutationSpermatozoaDNA, Mitochondrial

Identifiers

PMID40617230

DOI10.1016/j.gde.2025.102376

PMCPMC12277965

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.