Evidence map›Paper›PMID 40616988›Full record

ArticleTranslational oncology2025

Differential gene expression profiles of pancreatic ductal adenocarcinomas among African American and Caucasian American patients.

Prachi Bajpai, Ravi Paluri, Sameer Al Diffalha, Darshan S Chandrashekar, Farrukh Afaq, Dennis Otali, Amr Elkholy, C Ryan Miller, Shajan Peter, Ashish Manne and 5 more

Abstract read
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In one paragraph

Article in Translational oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Prachi BajpaiDepartment of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Ravi PaluriDepartment of Medicine, Division of Hematology and Oncology, Wake Forest School of Medicine, NC, USA.
Sameer Al DiffalhaDepartment of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Darshan S ChandrashekarDepartment of Pathology, Division of Genomic Diagnostics & Bioinformatics, University of Alabama at Birmingham, Birmingham, AL, USA.
Farrukh AfaqDepartment of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Dennis OtaliDepartment of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Amr ElkholyDepartment of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
C Ryan MillerDepartment of Pathology, Division of Neuropathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Shajan PeterDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Ashish ManneDepartment of Internal Medicine, Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Ganji Purnachandra NagarajuDepartment of Hematology and Oncology, School of Medicine, University of Alabama, Birmingham, AL, USA.
Madhu Sudhana SaddalaFunctional Genomics Core, University of California, Irvine, CA, USA.
Moh'd KhushmanDepartment of Medical Oncology, Division of Hematology and Oncology, Washington University in St. Louis/Siteman Cancer Center, St. Louis, MO, USA.
Sooryanarayana VaramballyDepartment of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; UAB O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA.
Upender ManneDepartment of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; UAB O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: upendermanne@uabmc.edu.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
NCI NIH HHS P30 CA013148
6 · The paper itself

Abstract

purposeIn the United States, African Americans (AA) have higher Pancreatic ductal adenocarcinoma (PDAC) incidence and mortality rates than Caucasian Americans (CA). This study aimed to identify distinct gene expression signatures and differentially regulated pathways in AA and CA PDACs.

methodsTranscriptomic analyses were conducted on FFPE sections of PDACs (n = 40) from AA (9 PDACs/3 normal) and CA (31 PDACs/5 normal) tissues to evaluate the differential expression and signaling pathways within and between racial groups and to identify distinctive and common genes/pathways.

resultsWe identified unique differentially expressed genes in both racial groups. Distinct set genes were modulated in AA and CA PDACs, compared to their respective normal tissues. Thirteen genes (seven upregulated and six downregulated) were differentially modulated in AA PDACs vs. CA PDACs. CIBERSORT analysis revealed distinct immune cell composition, with increased resting NK cells and activated mast cells, in AA PDACs, and higher CD4 memory T cells present in CA PDACs. Canonical subtype analyses indicated a more heterogenous subtype distribution in AA PDACs, whereas CA PDACs showed a predominance of classical subtypes. Using a publicly available database, we analyzed the top 25 upregulated genes (normal vs. tumor) for AA and CA racial groups and seven differentially upregulated genes in AA PDACs vs. CA PDACs comparison for associations with survival outcomes. Eight genes (CHST15, PARP15, NUDT16, SERPINB3, PADI1, H3C8, ZNF488, and LETM2) correlated with poor patient survival.

conclusionThese findings show distinct gene expression profiles and modulated pathways in AA and CA PDACs, supporting development of race-based therapeutic targets.

Indexed as

Gene expressionPDACSignaling pathwaysTranscriptomic analyses

Identifiers

PMID40616988
PMCPMC12271492

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.