Evidence map›Paper›PMID 40616798›Full record

ArticleUnited European gastroenterology journal2025

Burden of Alcohol-Related Liver Disease and Alcohol Use Disorder in Asia.

Pojsakorn Danpanichkul, Yanfang Pang, Kanokphong Suparan, Preenapun Saokhieo, Pimtawan Jatupornpakdee, Natchaya Polpichai, Tanawat Attachaipanich, Thanathip Suenghataiphorn, Andrew F Ibrahim, Polathep Vichitkunakorn and 6 more

Abstract read
In one paragraph

Article in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Pojsakorn DanpanichkulDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.ORCID https://orcid.org/0000-0002-9121-165X
Yanfang PangAffiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Kanokphong SuparanImmunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Preenapun SaokhieoFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Pimtawan JatupornpakdeeFaculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Natchaya PolpichaiDepartment of Internal Medicine, Weiss Memorial Hospital, Chicago, Illinois, USA.
Tanawat AttachaipanichDepartment of Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Thanathip SuenghataiphornDepartment of Internal Medicine, Griffin Hospital, Derby, Connecticut, USA.
Andrew F IbrahimTexas Tech University Health Sciences Center School of Medicine, Lubbock, Texas, USA.
Polathep VichitkunakornDepartment of Family and Preventive Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Sakkarin ChirapongsathornDivision of Gastroenterology, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.
Ashok ChoudhuryDepartment of Hepatology and Liver Transplant, Institute of Liver and Biliary Sciences, New Delhi, India.
Anand V KulkarniDepartment of Hepatology and Liver Transplantation, Asian Institute of Gastroenterology (AIG) Hospitals, Hyderabad, India.ORCID https://orcid.org/0000-0002-1240-1675
Karn WijarnpreechaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Phoenix, Arizona, USA.ORCID https://orcid.org/0000-0002-6232-6343
Apichat KaewdechGastroenterology and Hepatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.ORCID https://orcid.org/0000-0002-4058-5977
Suthat LiangpunsakulDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Funding

FKBP5 in the pathogenesis of alcohol-associated liver diseaseR01AA030312 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI Suthat Liangpunsakul · 2022 to 2026
$1.8M
Immunological Profiles and prognostic outcomes in patients with alcoholic hepatitisU01AA026917 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT · 2018 to 2022
$1.2M
Novel animal models to study miRNA-mediated alcoholic liver diseaseUH3AA026903 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI LIANGPUNSAKUL, SUTHAT · 2020 to 2022
$1.2M
CSRD VA I01 CX000361Department of Veterans Affairs Merit Award 1I01CX000361Faculty of Medicine, Prince of Songkla UniversityIndiana University School of MedicineNIAAA NIH HHS R01 AA030312NIAAA NIH HHS U01 AA026917NIAAA NIH HHS UH3 AA026903NIH HHS R01AA030312NIH HHS U01AA026917NIH HHS UH3AA026903
6 · The paper itself

Abstract

backgroundAs alcohol consumption continues to rise rapidly in Asia, research into its significant consequences, alcohol-related liver disease (ALD), and alcohol use disorder (AUD) is still limited.

objectiveThis study examines the burden of alcohol-related liver disease and alcohol use disorder in Asia from 2000 to 2021.

methodsWe analyzed data from the global burden of disease (GBD) Study 2021 to assess age-standardized prevalence, incidence, and mortality rates for alcohol-related liver disease and alcohol use disorder in Asia from 2000 to 2021.

resultsIn 2021, there were approximately 1.40 million cases of ALD, resulting in 175,370 deaths and 53.18 million cases of AUD, with 57,110 deaths. Asia accounted for 46.35% of the global prevalence of ALD (an increase of 6.87% since 2000) and 47.86% of the global prevalence of AUD (an increase of 0.82% since 2000). A 91.2% increase in crude ALD prevalence, incidence, and mortality from 2000 to 2021 in Asia was observed. South Asia exhibited the highest crude burden of ALD, while Central Asia had the highest age-standardized rate. Notably, ALD prevalence increased in South Asia (Annual Percent Change [APC]: 0.10%, 95% CI: 0.08-0.13) and Central Asia (APC: 0.88%, 95% CI: 0.79-0.97), even as other regions experienced declines.

conclusionsThis study reveals a disproportionately increasing burden of ALD and AUD in Asia compared with global trends, with significant variability across subregions. Central and South Asia are identified as the primary drivers of the burden associated with ALD and AUD in this region.

Indexed as

Alcohol DrinkingAlcoholismAlcohol-Related DisordersLiver Diseases, AlcoholicAdultAgedAsiaCost of IllnessFemaleGlobal Burden of DiseaseHumansIncidenceMaleMiddle AgedPrevalenceYoung Adultalcoholalcohol‐related liver diseasealcohol use disorderasiaepidemiologyglobalprevalence

Identifiers

PMID40616798
PMCPMC12528996

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.