Evidence map›Paper›PMID 40616791›Full record

ReviewEpilepsia2025

Tumor-related epilepsy in glioma: A multidisciplinary overview.

Roberto Michelucci, Giada Pauletto, Antonio Silvani, Elena Pasini, Tamara Ius, Matteo Martinoni, Carlo Alberto Castioni, Andrea Salmaggi, Sofia Asioli, Marta Maschio and 6 more

Abstract readReview
In one paragraph

Review in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
  2. Mapping integrated care for brain tumour-related epilepsy in the Italian RIN-IRCCS network.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Roberto MichelucciIRCCS Istituto delle Scienze Neurologiche di Bologna, Bellaria Hospital, Bologna, Italy.ORCID https://orcid.org/0000-0002-9655-7940
Giada PaulettoNeurology Unit, Head-Neck and Neurosciences Department, University Hospital of Udine, Udine, Italy.
Antonio SilvaniFondazione IRCCS Istituto Neurologico Carlo Besta, SC Neuro-Oncologia, Milan, Italy.
Elena PasiniIRCCS Istituto delle Scienze Neurologiche di Bologna, Bellaria Hospital, Bologna, Italy.ORCID https://orcid.org/0000-0001-6298-455X
Tamara IusAcademic Neurosurgery, Department of Neurosciences, University of Padua, Padua, Italy.
Matteo MartinoniIRCCS Istituto delle Scienze Neurologiche di Bologna, Bellaria Hospital, Bologna, Italy.
Carlo Alberto CastioniIRCCS Istituto delle Scienze Neurologiche di Bologna, Bellaria Hospital, Bologna, Italy.
Andrea SalmaggiDepartment of Neurosciences, Unit of Neurology, Presidio A. Manzoni, ASST Lecco, Lecco, Italy.
Sofia AsioliIRCCS Istituto delle Scienze Neurologiche di Bologna, Bellaria Hospital, Bologna, Italy.
Marta MaschioCenter for Tumor-Related Epilepsy, UOSD Neuro-Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Giuseppe MinnitiDepartment of Radiological Sciences, Oncology, and Anatomical Pathology, Sapienza University, Rome, Italy.ORCID https://orcid.org/0000-0003-1239-1603
Enrico FranceschiIRCCS Istituto delle Scienze Neurologiche di Bologna, Bellaria Hospital, Bologna, Italy.
Flavio VillaniIRCCS Ospedale Policlinico San Martino, Clinical Neurophysiology Unit and Epilepsy Center, Genoa, Italy.
Roberta RudàDivision of Neuro-Oncology, Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy.ORCID https://orcid.org/0000-0001-9134-1537
Eleonora AronicaDepartment of (Neuro)Pathology, Amsterdam Neuroscience, Amsterdam UMC location, University of Amsterdam, Amsterdam, the Netherlands.
Italian Multidisciplinary Group for Tumor Epilepsy

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor-related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an updated overview about the pathophysiological mechanisms and treatment options of TRE associated with gliomas, based on expert contributions belonging to different areas. By combining the most recent discoveries and expert opinions, this study seeks to provide useful advice for TRE management in glioma patients. To improve patient outcomes and quality of life, prospective, standardized, multicentric studies should be promoted to optimize TRE patient care and refine therapeutic approaches.

Indexed as

Brain NeoplasmsEpilepsyGliomaHumansQuality of Lifeantiseizure medicationscerebral tumorschemotherapyepilepsyepilepsy surgeryradiotherapy

Identifiers

PMID40616791
PMCPMC12605789

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.