ArticleEpilepsia2025
Functional network dynamics in photosensitive epilepsy depend on stimulation frequency and photoparoxysmal electroencephalographic response.
Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Photosensitive response mouse model: A potential tool for studying mechanisms of photosensitive epilepsy and initial screening of anti-epileptic drugs.The Journal of physiology · 2026Article
- Functional network dynamics in photosensitive epilepsy depend on stimulation frequency and photoparoxysmal electroencephalographic response.Epilepsia · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectivePhotosensitive epilepsy (PSE) is a reflex epilepsy, where abnormal electroencephalographic (EEG) responses are induced by photic stimulation. Photosensitivity is classified into four types based on the propagation of the brain's response to visual stimuli. Here, we aimed to describe the underlying dynamical mechanisms of PSE and different photosensitivity types.
methodsThis retrospective study included healthy controls (HC), PSE patients, and non-PSE patients with epilepsy (PWE). All participants were stimulated with flickering white light (1-60 Hz) under 10-20 EEG monitoring.
resultsWe observed significantly higher occipital photoparoxysmal response (PPR) power in PSE patients compared to HC for stimulation frequencies between 10 and 20 Hz. However, the excitability of the visual cortex, investigated by the occipital transient (P100) and steady-state visual evoked potentials (ssVEP), remained unchanged in most PSE types compared to HC and to PWE. The ssVEP power only increased significantly in PSE type 4 compared to HC. Instead, PSE patients exhibited notable differences in functional connectivity for stimulation frequencies of 10-20 Hz in the PPR band (3-4 Hz) relative to HC, characterized by centroparietal and centrofrontopolar hypoconnectivity. Additionally, for the same stimulation frequencies, PSE patients with PPR propagation showed occipitofrontocentral hyperconnectivity compared to both HC and PWE. SIGNIFICANCE: Our results provide novel evidence that altered network dynamics in PSE patients are likely a prerequisite for the propagation of the PPR and type-specific responses. PSE is a network effect modulated by anterior and anteroposterior hyperconnectivity, supported by a hyperexcitable visual cortex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.