Evidence map›Paper›PMID 40616774›Full record

ArticleProbiotics and antimicrobial proteins2026

Synergistic Effects of Pediococcus pentosaceus E24-168 and Exercise on Obesity-Related Dysfunctions and Anxiety in High-Fat Diet-Induced Obese Mice.

Haydar Bin Habib, Farzana Rahman Omi, Suvro Biswas, Mohasana Akter Mita, Suzzada Suhi, Shahriar Zaman, Md Akhtar-E- Ekram, Md Abu Saleh, Md Salah Uddin

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Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The therapeutic potential ofFrontiers in microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haydar Bin HabibDepartment of Physical Education and Sports Science, Faculty of Science, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Farzana Rahman OmiDepartment of Physical Education and Sports Science, Faculty of Science, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Suvro BiswasMicrobiology Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Mohasana Akter MitaMicrobiology Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Suzzada SuhiDepartment of Zoology, Faculty of Biological Sciences, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Shahriar ZamanMicrobiology Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Md Akhtar-E- EkramMicrobiology Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6205, Bangladesh.
Md Abu SalehMicrobiology Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6205, Bangladesh. saleh@ru.ac.bd.
Md Salah UddinDepartment of Physical Education and Sports Science, Faculty of Science, University of Rajshahi, Rajshahi, 6205, Bangladesh. salim.geb@ru.ac.bd.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a global health crisis associated with various metabolic and psychological dysfunctions, which requires a comprehensive therapeutic approach. This study aimed to assess the combined effects of Pediococcus pentosaceus E24-168 and exercise on obesity-related dysfunctions and anxiety in mice with high-fat diet (HFD)-induced obesity. Swiss Albino male mice were divided into five groups: control, HFD, HFD with exercise (HFD + Ex), HFD with Pediococcus pentosaceus E24-168 (HFD + PP), and HFD with both exercise and Pediococcus pentosaceus E24-168 (HFD + Ex + PP). After 35 days of treatment, behavioral tests were conducted on mice from each group, followed by biochemical and histological analyses. Results indicated that the HFD group experienced significant increases in body weight, blood glucose levels, anxiety-related behaviors, and tissue damage. The exercise-only group (HFD + Ex) and the probiotic-only group (HFD + PP) each showed moderate improvements in these areas. However, the combined intervention group (HFD + Ex + PP) exhibited the most pronounced benefits, including significant weight loss, improved biochemical markers, normalized glucose and lipid profiles, decreased liver enzyme activity, reduced anxiety behaviors, and enhanced histological outcomes. These findings suggest that the combination of Pediococcus pentosaceus E24-168 and exercise may be a highly effective therapeutic strategy for addressing metabolic and psychological dysfunctions associated with obesity.

Indexed as

AnxietyObesityPediococcus pentosaceusPhysical Conditioning, AnimalProbioticsAnimalsBody WeightDiet, High-FatMaleMiceMice, ObeseAnxiety-related behaviorsExerciseHigh-fat diet (HFD)Metabolic dysfunctionsObesityProbiotics

Identifiers

PMID40616774

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.