Evidence map›Paper›PMID 40616768›Full record

ArticleInfectious diseases and therapy2025

Impact of Continuous Renal Replacement Therapy with Polyacrylonitrile-Derived Filter on Caspofungin Concentration: A Retrospective Study.

Romain Arrestier, Claire Pressiat, Laura Bouabdallah, Paul Masi, Nicolas Mongardon, Anne Hulin, Armand Mekontso Dessap, Keyvan Razazi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious diseases and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Romain ArrestierService de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 51 Avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France. romain.arrestier@aphp.fr.ORCID http://orcid.org/0000-0002-6779-5368
Claire PressiatLaboratoire de Pharmacologie, DMU Biologie-Pathologie, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France.ORCID http://orcid.org/0000-0003-0728-2701
Laura BouabdallahService de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 51 Avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France.
Paul MasiService de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 51 Avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France.ORCID http://orcid.org/0000-0002-5817-2257
Nicolas MongardonService d'Anesthésie-Réanimation et Médecine Péri-Opératoire, DMU CARE, DHU A-TVB, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Créteil, France.ORCID http://orcid.org/0000-0003-2756-4052
Anne HulinLaboratoire de Pharmacologie, DMU Biologie-Pathologie, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France.ORCID http://orcid.org/0000-0001-9430-9866
Armand Mekontso DessapService de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 51 Avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France.ORCID http://orcid.org/0000-0001-5961-5577
Keyvan RazaziService de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, 51 Avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France.ORCID http://orcid.org/0000-0001-7979-2650

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCaspofungin pharmacokinetics may be altered in critically ill patients. In vitro studies suggest significant drug adsorption with polyacrylonitrile (PAN) membranes during continuous renal replacement therapy (CRRT).

methodsThis study retrospectively analyzed 66 plasma caspofungin concentrations (pCAS

resultsCaspofungin is mainly prescribed for candidemia (40%) and invasive Candida infections (25.7%). Median pCAS

conclusionThis study found no evidence of caspofungin depletion with PAN-CRRT, warranting further research on clinical outcomes.

Indexed as

CaspofunginContinuous renal replacement therapyEchinocandinPharmacokineticTherapeutic drug monitoring

Identifiers

PMID40616768
PMCPMC12339816

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.