Evidence map›Paper›PMID 40616764›Full record

ArticleEndocrine2025

Comparison of different criteria of captopril challenge test for the diagnosis of primary aldosteronism.

Qiang Fu, Shili Peng, Yixin Zhang, Ying Song, Jinbo Hu, Qifu Li, Yifan He, Shumin Yang, Yue Wang, Chongqing Primary Aldosteronism Study (CONPASS) Group

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qiang Fu *Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shili Peng *Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yixin ZhangDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ying SongDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jinbo HuDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qifu LiDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yifan HeDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. mors_hyf@hotmail.com.ORCID 0000-0002-5008-1983
Shumin YangDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 443068494@qq.com.ORCID 0000-0002-0238-4779
Yue WangDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 469126022@qq.com.ORCID 0000-0002-5478-5582
Chongqing Primary Aldosteronism Study (CONPASS) Group

Funding

Chongqing Outstanding Youth Science Fund project CSTB2023NSCQ-JQX0028National key research & development plan of China, Project of prevention and treatment for common diseases 2022YFC2505301National key research & development plan of China, Project of prevention and treatment for common diseases 2022YFC2505302National key research & development plan of China, Project of prevention and treatment for common diseases 2022YFC2505306
6 · The paper itself

Abstract

objectivesThe Captopril Challenge Test (CCT) is favored in the diagnosis of primary aldosteronism (PA) for its simplicity and high patient compliance, yet optimal diagnostic criteria for CCT remain controversial. This study compared the accuracy of different CCT criteria for the diagnosis of PA.

methodsThis study included retrospective and prospective cohorts. High-risk PA patients were enrolled to complete aldosterone-to-renin ratio (ARR) screening, CCT, and the saline infusion test (SIT). SIT was used as the reference standard, and receiver operating characteristic (ROC) curves were constructed to evaluate the diagnostic accuracy.

resultsThe retrospective cohort included 871 patients with PA and 464 with EH. The AUC for PAC post-CCT in diagnosing PA was 0.90, significantly higher than that of ARR post-CCT (0.73) or PAC suppression percentage (0.72). The prospective cohort included 134 patients with PA and 162 with EH, showing an AUC for PAC post-CCT of 0.89, significantly higher than that of ARR post-CCT (0.71) or PAC suppression percentage (0.58). Using a PAC post-CCT cutoff of 11 ng/dL for diagnosing PA achieved a sensitivity of 0.89 and specificity of 0.66 in the retrospective cohort, and a sensitivity of 0.77 and specificity of 0.84 in the prospective cohort, respectively.

conclusionPAC post-CCT served as a superior indicator for the diagnosis of PA, with 11 ng/dL recommended as the optimal diagnostic cutoff.

Indexed as

CaptoprilHyperaldosteronismAdultAgedAldosteroneFemaleHumansMaleMiddle AgedProspective StudiesReninRetrospective StudiesSensitivity and SpecificityAldosteroneCaptoprilReninCaptopril challenge testCutoffDiagnosisPrimary aldosteronism

Identifiers

PMID40616764

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