Evidence map›Paper›PMID 40616749›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2025

Enhanced visual illusions in Parkinson's disease with cardiovascular autonomic failure.

Tadashi Umehara, Masahiro Mimori, Tatsushi Kokubu, Masakazu Ozawa, Tomotaka Shiraishi, Asako Onda, Hiromasa Matsuno, Shusaku Omoto, Hidetomo Murakami, Yasuyuki Iguchi

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Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tadashi UmeharaDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan. tumety@jikei.ac.jp.ORCID http://orcid.org/0000-0003-4156-5617
Masahiro MimoriDepartment of Neurology, Katsushika Medical Center, The Jikei University School of Medicine, Tokyo, Japan.
Tatsushi KokubuDepartment of Neurology, Atsugi City Hospital, Atsugi, Japan.
Masakazu OzawaDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Tomotaka ShiraishiDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Asako OndaDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Hiromasa MatsunoDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Shusaku OmotoDepartment of Neurology, Katsushika Medical Center, The Jikei University School of Medicine, Tokyo, Japan.
Hidetomo MurakamiDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.
Yasuyuki IguchiDepartment of Neurology, The Jikei University School of Medicine, 3-19-18, Tokyo, 105-8471, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFew studies have examined the association between cardiovascular autonomic failure and minor hallucinations in patients with Parkinson's disease (PD). The aim of this study was to clarify this association.

methodsThe subjects were 133 patients with PD without well-structured visual hallucinations. Visual illusory responses were evaluated using the noise pareidolia test. Cardiac

resultsFifty-one (38%) patients had pareidolia. nOH (β = 0.220, p = 0.008), cognitive impairment (β = -0.228, p = 0.028), and longer symptom duration (β = 0.273, p = 0.006) were associated with an increased incidence of pareidolia independently of age, sex, motor severity, levodopa-equivalent dose, and anticholinergic and cholinesterase inhibitor use. An increased incidence of pareidolia was also associated with nSH (β = 0.214, p = 0.009), while no such association was found with cardiac

conclusionnOH and nSH were associated with the severity of pareidolia in early PD patients without well-structured visual hallucinations. Further studies are required to clarify whether this association is attributable to widespread central pathological changes related to cardiovascular autonomic failure, or to degeneration of the sympathetic nervous system.

Indexed as

Autonomic Nervous System DiseasesHallucinationsIllusionsParkinson Disease3-IodobenzylguanidineAgedFemaleHumansHypotension, OrthostaticMaleMiddle AgedTilt-Table Test3-IodobenzylguanidineMinor hallucinationOrthostatic hypotensionPareidoliaParkinson’s diseaseSupine hypertension

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PMID40616749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.