ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025
Length of mobile phone use mediating the effect of major depression on low back pain/sciatica: a mendelian randomization study.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeAccumulating evidence indicates an association between major depression (MD) and the occurrence of low back pain/sciatica (LBP/S). In order to examine this association, we conducted a Mendelian randomization (MR) study, further evaluating the extent to which the length of mobile phone use mediates the impact of MD on the risk of developing LBP/S.
methodsGenetic instruments and association estimates for MD, LBP/S, and length of mobile phone use were extracted from existing Genome-wide Association Study (GWAS) summary data. Bidirectional two-sample MR analyses were conducted to investigate the influence of MD on the risk of LBP/S. Furthermore, MR mediation analyses were executed to evaluate whether the length of mobile phone use mediates any effect of MD on LBP/S.
resultsMR analyses showed that a higher genetic risk for MD increased the odds of LBP/S (odds ratio [OR] 1.241; 95% confidence interval [CI], 1.065-1.446). The mediation analysis, employing a two-step MR approach, indicated that the observed effect was partially mediated by the length of mobile phone use, accounting for a mediated proportion of 12.0% (95% CI, 2.3-25.0%).
conclusionThese findings may serve as a foundation for devising preventive strategies and interventions aimed at regulating the length of mobile phone use for individuals grappling with LBP/S in the context of MD.
Indexed as
Identifiers
40616671What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.