SynthesisLasers in medical science2025
The clinical efficacy of laser-assisted open flap debridement in patients with periodontitis: a systematic review and meta-analysis.
Synthesis in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hyperglycemic microenvironment-driven periodontal tissue defects: pathogenic mechanisms and therapeutic advances.Frontiers in dental medicine · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe aim of this meta-analysis was to assess the quality of evidence and efficacy of laser-assisted open flap debridement (OFD) in the treatment of periodontitis.
methodsThis systematic review and meta-analysis followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and was registered in the PROSPERO (CRD42024613819). We searched PubMed, Web of Science, Cochrane Library for studies up to September 15,2024 that compared of laser-assisted OFD with OFD alone. The primary outcome indicator was clinical attachment level (CAL) and the secondary outcome indicators were PD, PI, BI. Random or fixed-effects meta-analytical models were used, depending on the results of the heterogeneity assessment.
resultsA total of 69 titles and abstracts are searched, and 12 RCTs are included in this Meta-analysis. The Meta-analysis shows that, at the 6-month postoperative follow-up, patients in the laser-assisted OFD experimental group exhibit a reduction in CAL [MD = -0.57, 95%CI: (-0.88, -0.25), P = 0.0004] and a decrease in probing depth (PD) [MD = -0.31, 95%CI (-0.57, -0.05), P = 0.02], with these differences being significant. However, the declines in plaque index (PI) [MD = -0.03, 95%CI (-0.17, 0.11), P = 0.66] and gingival index (GI) [MD = 0.01, 95%CI: (-0.05, 0.07), P = 0.77] do not manifest statistically significant differences.
conclusionWith the limited data available, compared with OFD, laser-assisted OFD can achieve better therapeutic effects in the treatment of periodontitis. Moreover, since the laser parameters and treatment protocols of the included studies were unstandardized and have no direct comparability, further RCTs are required to draw a more realistic and reliable conclusion.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.