Evidence map›Paper›PMID 40616643›Full record

ReviewMolecular diversity2026

Unraveling the secrets of novel PROTACs to improve degradation efficacy.

Juan Huang, Xiaoyan Yang, Qiuqian Huang, Yangyang Gao, Pradeepa C G Bandaranayake, Wishwajith Kandegama, Charles R Ashby, Yawen Dong, Zhenchao Wang, Ge-Fei Hao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juan Huang *School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, Guizhou, People's Republic of China.
Xiaoyan Yang *State Key Laboratory of Green Pesticide; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, People's Republic of China.
Qiuqian HuangState Key Laboratory of Green Pesticide; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, People's Republic of China.
Yangyang GaoState Key Laboratory of Green Pesticide; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, People's Republic of China.
Pradeepa C G BandaranayakeAgricultural Biotechnology Center, Faculty of Agriculture, University of Peradeniya, Peradeniya, Sri Lanka.
Wishwajith KandegamaState Key Laboratory of Green Pesticide; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, People's Republic of China.
Charles R AshbyDepartment of Pharmaceutical Sciences, St. John's University, New York, NY, 11439, USA.
Yawen DongSchool of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, Guizhou, People's Republic of China. dongyw@gzu.edu.cn.
Zhenchao WangSchool of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, Guizhou, People's Republic of China. wzc.4884@163.com.
Ge-Fei HaoState Key Laboratory of Green Pesticide; Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, People's Republic of China. gefei_hao@foxmail.com.

Funding

Guizhou Province Science and Technology Foundation, China QKHJC-zk[2025]MS652National Key Research and Development Program of China No. 2024YFE0214300National Natural Science Foundation of China No. 32260688Program of Major Scientific and Technological, Guizhou Province, China QKHCG(2024)ZD007
6 · The paper itself

Abstract

Proteolysis targeting chimera (PROTAC) represents a crucial approach for overcoming various limitations associated with traditional inhibitors, particularly in targeting "undruggable" proteins and overcoming the resistance of targets. The degradation efficiency of PROTAC is fundamental to its pharmacological activity. Improving PROTAC's degradation efficiency mainly focuses on small molecule design, exploring new mechanisms, and optimizing delivery strategies. However, there is a lack of comprehensive understanding regarding how novel PROTACs enhance degradation efficacy. Here, a comprehensive exploration of novel PROTACs has been conducted to reveal the mechanisms of enhanced degradation efficiency through an in-depth analysis of tremendous existing studies. Firstly, we describe the variables influencing PROTAC's degradation activity. Secondly, a complete analysis is launched between novel PROTACs and their traditional counterparts, elucidating the reasons for the improved degradation efficacy of newer forms. Finally, the successful cases are leveraged to verify the theoretical foundation underlying enhanced degradation efficacy. We believe this work is anticipated to offer new perspectives for the design and guide the creation of potent PROTACs.

Indexed as

ProteolysisProteolysis Targeting ChimeraDrug DesignHumansProteolysis Targeting ChimeraDegradation efficacyMechanism analysisNovel PROTACsRational designStructural optimization

Identifiers

PMID40616643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.