Evidence map›Paper›PMID 40616631›Full record

ArticleOdontology2026

The impact of radiotherapy on endodontic treatment: a scoping review.

Guilherme Pauletto, Giovanna Isabel Mittmann Voigt, Sidnei Flores de Pellegrin, Yasmin Padoin, Carlos Alexandre Souza Bier

Abstract readScoping Review
PubMed Publisher
In one paragraph

Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Evidence supporting endodontic therapy as a safe strategy in patients previously treated with head and neck radiotherapy: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guilherme PaulettoFaculty of Dentistry, Federal University of Santa Maria (UFSM), Roraima Avenue #1000, T Street, Building 26F, Room 2383, Santa Maria, Rio Grande do Sul State, 97.105-900, Brazil. guilhermepauletto@hotmail.com.ORCID http://orcid.org/0000-0002-7524-0370
Giovanna Isabel Mittmann VoigtFaculty of Dentistry, Federal University of Santa Maria (UFSM), Roraima Avenue #1000, T Street, Building 26F, Room 2383, Santa Maria, Rio Grande do Sul State, 97.105-900, Brazil.
Sidnei Flores de PellegrinFaculty of Dentistry, Federal University of Santa Maria (UFSM), Roraima Avenue #1000, T Street, Building 26F, Room 2383, Santa Maria, Rio Grande do Sul State, 97.105-900, Brazil.
Yasmin PadoinFaculty of Dentistry, Federal University of Santa Maria (UFSM), Roraima Avenue #1000, T Street, Building 26F, Room 2383, Santa Maria, Rio Grande do Sul State, 97.105-900, Brazil.
Carlos Alexandre Souza BierFaculty of Dentistry, Federal University of Santa Maria (UFSM), Roraima Avenue #1000, T Street, Building 26F, Room 2383, Santa Maria, Rio Grande do Sul State, 97.105-900, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This scoping review aimed to map how radiotherapy can influence endodontic treatment. The protocol of this review is available online ( https://osf.io/aq7fv/ ). The report followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. A structured search was conducted in PubMed, Embase, Scopus, and Web of Science up to September 2024. Studies that assessed the influence of radiotherapy on the interaction between endodontic sealers and root dentin, the biomechanical behavior of endodontically treated teeth, and the success rates of therapy were included. There were no restrictions on publication date or language, and in vitro studies, observational studies, and experimental clinical studies were eligible. Two researchers independently selected the articles and extracted the data. Out of 1748 studies identified, 18 met the inclusion criteria-13 in vitro studies and 5 observational studies. Most studies used fixed radiation doses, with radiotherapy administered before endodontic treatment. The results of the in vitro studies demonstrated that radiotherapy reduced the bond strength in all studies for at least one of the tested sealers, significantly increased the amount of residual filling material during retreatment and did not negatively affect apical sealing ability. Moreover, radiotherapy influenced the biomechanical behavior of both intact and endodontically treated teeth. However, the findings of observational studies regarding clinical success rates remain controversial. The reviewed evidence suggests that radiotherapy may impact endodontic treatment outcomes in the mapped contexts. However, the available data are limited and further research is needed to strengthen the evidence in this field.

Indexed as

RadiotherapyRoot Canal TherapyHumansDentistryEndodonticsHead and neck neoplasmsRadiation therapyRoot canal therapy

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.