Evidence map›Paper›PMID 40616615›Full record

ArticleJournal of molecular histology2025

Impaired therapeutic efficacy of sleep-deprived bone marrow mesenchymal stem cells in the cerebellum of mouse cuprizone model of multiple sclerosis: stereological and motor behavioral evidence.

Shiva Amirizadeh, Parichehr Pasbakhsh, Saleh Omairi, Iraj Ragerdi Kashani, Maedeh Hashemi, Davood Zarini, Reza Asadi-Golshan

Abstract read
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In one paragraph

Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shiva AmirizadehDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, 1461884513, Iran.ORCID http://orcid.org/0009-0000-1975-0133
Parichehr PasbakhshDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, 1461884513, Iran.ORCID http://orcid.org/0009-0009-8659-6442
Saleh OmairiDepartment of Human Anatomy, College of Medicine, Wasit University, Kut, Iraq.ORCID http://orcid.org/0000-0001-9169-3743
Iraj Ragerdi KashaniDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, 1461884513, Iran.ORCID http://orcid.org/0000-0003-3842-7950
Maedeh HashemiDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, 1461884513, Iran.ORCID http://orcid.org/0000-0003-3203-9842
Davood ZariniDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, 1461884513, Iran.ORCID http://orcid.org/0000-0002-9264-7738
Reza Asadi-GolshanDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, 1461884513, Iran. asadigr@ymail.com.ORCID http://orcid.org/0000-0003-1901-7171

Funding

Tehran University of Medical Sciences and Health Services 55550
6 · The paper itself

Abstract

Multiple sclerosis (MS) leads to histological changes, which in turn result in functional deficits. Studies have reported that bone marrow mesenchymal stem cells (BMSCs) have therapeutic benefits in MS. In addition, sleep deprivation affects therapeutic potential of BMSCs. This research aimed to evaluate the effects of BMSCs compared to sleep-deprived BMSCs (SD-BMSCs) on the motor behavior and histological recovery in MS. The mice were divided into four groups receiving cuprizone for five weeks, with or without intranasal administration of cells (BMSCs or SD-BMSCs) after five weeks. After a two-week recovery period, balance beam and pole tests were performed to assess motor performance, followed by estimation of histological parameters using stereological methods. Mice that received BMSCs scored significantly better than the SD-BMSC group in balance beam and pole tests (P < 0.05). The total cerebellar volume, cortex, and white matter volumes, as well as the total number of Purkinje cells in mice that received BMSCs, were significantly higher compared to those in the SD-BMSC group (P < 0.05). Intranasal administration of BMSCs leads to significantly improved motor behavior and histological regeneration of the cerebellum, including cortex and white matter as well as Purkinje cells compared to SD-BMSCs in a cuprizone model of multiple sclerosis.

Indexed as

CerebellumMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMultiple SclerosisSleep DeprivationAnimalsBehavior, AnimalCuprizoneDisease Models, AnimalMaleMiceMotor ActivityCuprizoneCerebellumMesenchymal stem cellMultiple sclerosisPurkinje cellSleep deprivationStereology

Identifiers

PMID40616615

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.