Evidence map›Paper›PMID 40616455›Full record

ReviewNeurodegenerative disease management2025

Recent and on-going trials for the treatment of levodopa-induced dyskinesia: a review of the clinical trial databases.

Jawad Al-Kassmy, Mohammed Alsalmi, Woojin Kang, Michael Palayew, Philippe Huot

Abstract readReview
In one paragraph

Review in Neurodegenerative disease management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jawad Al-KassmyRoyal College of Surgeons in Ireland, School of Medicine, Dublin, Ireland.ORCID 0000-0003-4547-1781
Mohammed AlsalmiDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
Woojin KangNeurodegenerative Disease Group, Montreal Neurological Institute-Hospital (The Neuro), Montreal, QC, Canada.
Michael PalayewRoyal College of Surgeons in Ireland, School of Medicine, Dublin, Ireland.
Philippe HuotDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.ORCID 0000-0002-5464-8334

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-3,4-dihydroxyphenylalanine (Levodopa)-induced dyskinesia remains a condition for which there are few therapeutic options available. Fortunately, the past 5 years have seen the completion of several clinical trials, some of which yielded positive and encouraging results. Here, we performed a review of the clinical trials that were completed or for which outcomes were disclosed within the past 5 years. Promising results were obtained in Phase II trials with the serotonin type 1A (5-HT

Indexed as

Antiparkinson AgentsClinical Trials as TopicDyskinesia, Drug-InducedLevodopaHumansAntiparkinson AgentsLevodopaclinical trialsdrugsdyskinesialevodopaParkinson’s disease

Identifiers

PMID40616455
PMCPMC12456213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.