ArticleHead & neck2025
Detection of Circulating Cancer-Associated Fibroblasts in Head and Neck Squamous Cell Carcinoma and Their Impact on Circulating Tumor Cells.
Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- T-Cell Receptor and Immune Gene Expression Pharmacodynamics for Durvalumab Alone and with Tremelimumab or Bevacizumab in Unresectable Hepatocellular Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Trial
- Inter- and intra-quartile comparison of multi-tracer PET/CT and liquid biopsy molecular markers in cancer: a futuristic perspective on evolving a "stepped care" model for individualized precision theranostics through AI/ML.European journal of nuclear medicine and molecular imaging · 2026Article
- Review
- Cancer-Associated Fibroblast Heterogeneity Shapes Prognosis and Immune Landscapes in Head and Neck Squamous Cell Carcinoma.Cancers · 2026Article
- Unraveling the impact of cancer-associated fibroblasts on lymphatic metastasis of head and neck squamous cell carcinoma.Cellular oncology (Dordrecht, Netherlands) · 2025Review
- Circulating tumour cells and circulating tumour DNA in head and neck cancer: from molecular insights to clinical impact.Cancer metastasis reviews · 2025Review
- Detection of Circulating Cancer-Associated Fibroblasts in Head and Neck Squamous Cell Carcinoma and Their Impact on Circulating Tumor Cells.Head & neck · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLike tumor cells, cancer-associated fibroblasts (CAFs) can enter the bloodstream and may function in systemic circulation.
methodsCirculating CAFs (cCAFs) were isolated from the peripheral blood of head and neck squamous cell carcinoma (HNSCC) patients using CD45 depletion and detected by FAP expression using RT-qPCR. Circulating tumor cells (CTCs) were detected through the expression of epithelial markers (EPCAM, EGFR, and MET). We analyzed the association between cCAF positivity and clinical factors, CTC characteristics, and verified tumor tissue relationships using public datasets.
resultsOf the 97 patients, 19.6% were positive for cCAFs and 61.9% for CTCs. cCAF positivity was significantly associated with lymph node metastasis, CTC positivity, and lower EPCAM levels on CTCs. In tumor tissues, FAP expression inversely correlated with EPCAM expression in tumor cells.
conclusioncCAFs may contribute to the survival of CTCs and tumor progression through changes in the characteristics of CTCs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.