Evidence map›Paper›PMID 40616372›Full record

ArticleInternational journal of toxicology

Safety and Toxicological Evaluation of Subunit Keyhole Limpet Hemocyanin-Loaded Lipid-PLGA Hybrid Nanoparticles (sKLH-hNPs) as a Nanocarrier for an Opioid Use Disorder Vaccine.

Debra Walter, Qiaoqiao Ci, He Hu, Riley DeHority, Jonathan Hinckley, Yuanzhi Bian, Priscila B S Serpa, Teresa Southard, Stephen R Werre, Marco Pravetoni and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Debra WalterDepartment of Biological Systems Engineering, College of Engineering & College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA, USA.
Qiaoqiao CiDepartment of Biological Systems Engineering, College of Engineering & College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA, USA.ORCID 0009-0005-2989-2270
He HuDepartment of Biological Systems Engineering, College of Engineering & College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA, USA.
Riley DeHorityDepartment of Biological Systems Engineering, College of Engineering & College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA, USA.
Jonathan HinckleyDepartment of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.
Yuanzhi BianDepartment of Biological Systems Engineering, College of Engineering & College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA, USA.ORCID 0009-0001-0585-3251
Priscila B S SerpaDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.
Teresa SouthardDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.
Stephen R WerreDepartment of Population Health Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.
Marco PravetoniDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, WA, USA.
Marion EhrichDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0002-5466-4203
Chenming ZhangDepartment of Biological Systems Engineering, College of Engineering & College of Agricultural and Life Sciences, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0002-6770-5334

Funding

Novel nanovaccines against opioid use disordersUG3DA048775 · NIDA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI PRAVETONI, MARCO, ZHANG, CHENMING M · 2019 to 2020
$3.1M
NIDA NIH HHS UG3 DA048775
6 · The paper itself

Abstract

A nanoparticle-based immunization strategy offers a promising treatment for opioid use disorder (OUD). This study tested the

Indexed as

Drug CarriersHemocyaninsNanoparticlesOpioid-Related DisordersVaccinesAnimalsBehavior, AnimalLipidsMaleMiceMice, Inbred BALB CPolylactic Acid-Polyglycolic Acid CopolymerDrug CarriersHemocyaninskeyhole-limpet hemocyaninLipidsPolylactic Acid-Polyglycolic Acid CopolymerVaccineshybrid nanoparticlesnanocarrier safetyopioid use disorderopioid vaccinesafety study

Identifiers

PMID40616372
PMCPMC12266659

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.